HBB_MACFA
ID HBB_MACFA Reviewed; 147 AA.
AC P68223; P02027; Q9TSL4;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Hemoglobin subunit beta;
DE AltName: Full=Beta-globin;
DE AltName: Full=Hemoglobin beta chain;
GN Name=HBB;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-121.
RX PubMed=3110424; DOI=10.1007/bf02134129;
RA Savatier P., Trabuchet G., Chebloune Y., Faure C., Verdier G., Nigon V.M.;
RT "Nucleotide sequence of the beta-globin genes in gorilla and macaque: the
RT origin of nucleotide polymorphisms in human.";
RL J. Mol. Evol. 24:309-318(1987).
RN [2]
RP PROTEIN SEQUENCE OF 2-147.
RX PubMed=5499429; DOI=10.1016/0005-2795(70)90216-3;
RA Wade P.T., Barnicot N.A., Huehns E.R.;
RT "Structural studies on the major and minor haemoglobin of the monkey Macaca
RT irus.";
RL Biochim. Biophys. Acta 221:450-466(1970).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 107-147.
RC TISSUE=Blood;
RX PubMed=10723742; DOI=10.1093/oxfordjournals.molbev.a026321;
RA Francino M.P., Ochman H.;
RT "Strand symmetry around the beta-globin origin of replication in
RT primates.";
RL Mol. Biol. Evol. 17:416-422(2000).
CC -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; X05665; CAA29153.1; -; Genomic_DNA.
DR EMBL; AF205410; AAF23761.1; -; Genomic_DNA.
DR PIR; A29665; HBMQC.
DR RefSeq; NP_001270296.1; NM_001283367.1.
DR AlphaFoldDB; P68223; -.
DR SMR; P68223; -.
DR STRING; 9541.XP_005578972.1; -.
DR GeneID; 101926697; -.
DR eggNOG; KOG3378; Eukaryota.
DR OrthoDB; 1370439at2759; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Heme; Iron; Metal-binding;
KW Oxygen transport; Phosphoprotein; Reference proteome; S-nitrosylation;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P02086,
FT ECO:0000269|PubMed:5499429"
FT CHAIN 2..147
FT /note="Hemoglobin subunit beta"
FT /id="PRO_0000053000"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT MOD_RES 2
FT /note="N-acetylvaline"
FT /evidence="ECO:0000250|UniProtKB:P02086"
FT MOD_RES 13
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P68871"
FT MOD_RES 45
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P68871"
FT MOD_RES 60
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P68871"
FT MOD_RES 83
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P68871"
FT MOD_RES 94
FT /note="S-nitrosocysteine"
FT /evidence="ECO:0000250|UniProtKB:P68871"
FT MOD_RES 145
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P68871"
SQ SEQUENCE 147 AA; 16114 MW; 1F796B304891A55B CRC64;
MVHLTPEEKN AVTTLWGKVN VDEVGGEALG RLLVVYPWTQ RFFESFGDLS SPDAVMGNPK
VKAHGKKVLG AFSDGLNHLD NLKGTFAQLS ELHCDKLHVD PENFKLLGNV LVCVLAHHFG
KEFTPQVQAA YQKVVAGVAN ALAHKYH