AN34C_HUMAN
ID AN34C_HUMAN Reviewed; 535 AA.
AC P0C6C1; H3BNM1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2013, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Ankyrin repeat domain-containing protein 34C;
GN Name=ANKRD34C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- SIMILARITY: Belongs to the ANKRD34 family. {ECO:0000305}.
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DR EMBL; AC011797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS53965.1; -.
DR RefSeq; NP_001139813.1; NM_001146341.1.
DR AlphaFoldDB; P0C6C1; -.
DR SMR; P0C6C1; -.
DR BioGRID; 133634; 34.
DR STRING; 9606.ENSP00000401089; -.
DR GlyGen; P0C6C1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; P0C6C1; -.
DR PhosphoSitePlus; P0C6C1; -.
DR BioMuta; ANKRD34C; -.
DR DMDM; 519668660; -.
DR PaxDb; P0C6C1; -.
DR PeptideAtlas; P0C6C1; -.
DR PRIDE; P0C6C1; -.
DR ProteomicsDB; 41238; -.
DR ProteomicsDB; 52326; -.
DR Antibodypedia; 68063; 63 antibodies from 11 providers.
DR DNASU; 390616; -.
DR Ensembl; ENST00000421388.4; ENSP00000401089.2; ENSG00000235711.5.
DR GeneID; 390616; -.
DR KEGG; hsa:390616; -.
DR MANE-Select; ENST00000421388.4; ENSP00000401089.2; NM_001146341.2; NP_001139813.1.
DR UCSC; uc059mho.1; human.
DR CTD; 390616; -.
DR GeneCards; ANKRD34C; -.
DR HGNC; HGNC:33888; ANKRD34C.
DR HPA; ENSG00000235711; Tissue enriched (brain).
DR neXtProt; NX_P0C6C1; -.
DR OpenTargets; ENSG00000235711; -.
DR VEuPathDB; HostDB:ENSG00000235711; -.
DR eggNOG; ENOG502QW3G; Eukaryota.
DR GeneTree; ENSGT00880000138051; -.
DR HOGENOM; CLU_042805_0_0_1; -.
DR InParanoid; P0C6C1; -.
DR OMA; VACMSTH; -.
DR OrthoDB; 466691at2759; -.
DR PhylomeDB; P0C6C1; -.
DR TreeFam; TF331155; -.
DR PathwayCommons; P0C6C1; -.
DR BioGRID-ORCS; 390616; 8 hits in 1058 CRISPR screens.
DR GenomeRNAi; 390616; -.
DR Pharos; P0C6C1; Tdark.
DR PRO; PR:P0C6C1; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; P0C6C1; protein.
DR Bgee; ENSG00000235711; Expressed in Brodmann (1909) area 23 and 66 other tissues.
DR Genevisible; P0C6C1; HS.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR042637; AN34A/B/C.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24156; PTHR24156; 1.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 3: Inferred from homology;
KW ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..535
FT /note="Ankyrin repeat domain-containing protein 34C"
FT /id="PRO_0000319104"
FT REPEAT 10..39
FT /note="ANK 1"
FT REPEAT 43..80
FT /note="ANK 2"
FT REPEAT 84..114
FT /note="ANK 3"
FT REPEAT 118..147
FT /note="ANK 4"
FT REGION 159..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 301
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BLB8"
FT MOD_RES 447
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BLB8"
FT VARIANT 369
FT /note="P -> R (in dbSNP:rs410400)"
FT /id="VAR_038953"
FT VARIANT 427
FT /note="P -> H (in dbSNP:rs449340)"
FT /id="VAR_038954"
FT VARIANT 442
FT /note="L -> I (in dbSNP:rs422777)"
FT /id="VAR_038955"
SQ SEQUENCE 535 AA; 58256 MW; 8B2757427F9F3686 CRC64;
MMDDDTELRT DGNSLLKAVW LGRLRLTRLL LEGGAYINES NDKGETALMV ACITKHVDQQ
SISKSKMVKY LLDNRADPNI QDKSGKTALI HACIRRAGGE VVSLLLENGA DPSLEDRTGA
SALVYAINAD DKDALKHLLD ACKAKGKEVI IITTDKSSSG TKTTKQYLNV PPSPKVEDRH
SPPLCASPSD IELKALGLDS PLTEKEDDFF SLQAGHPSSC NTSKAVNEPG SPTRKVSNLK
RARLPQLKRL QSEPWGLIAP SVLAASTRQD ETHGASTDNE VIKSISDISF PKRGPLSRTN
SIDSKDPTLF HTVTEQVLKI PVSSAPASWK AAYEKGQAPH PRLARRGTLP VDQEKCGMGP
SGPSALKEPA SLKWLENDLY DLDIQPGPDP PNSISLESGK GPLDRKKLNS SHLSLFHGSR
ESLDTVPSTS PSSARRRPPH LLERRGSGTL LLDRISHTRP GFLPPLNVNL NPPIPDIRSS
SKPSCSLASG LKSMVPVAPS SPKRVDLRSK KKLLRRHSMQ IEQMKQLSDF EEIMT
