位置:首页 > 蛋白库 > AN34C_HUMAN
AN34C_HUMAN
ID   AN34C_HUMAN             Reviewed;         535 AA.
AC   P0C6C1; H3BNM1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2013, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Ankyrin repeat domain-containing protein 34C;
GN   Name=ANKRD34C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
CC   -!- SIMILARITY: Belongs to the ANKRD34 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC011797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS53965.1; -.
DR   RefSeq; NP_001139813.1; NM_001146341.1.
DR   AlphaFoldDB; P0C6C1; -.
DR   SMR; P0C6C1; -.
DR   BioGRID; 133634; 34.
DR   STRING; 9606.ENSP00000401089; -.
DR   GlyGen; P0C6C1; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; P0C6C1; -.
DR   PhosphoSitePlus; P0C6C1; -.
DR   BioMuta; ANKRD34C; -.
DR   DMDM; 519668660; -.
DR   PaxDb; P0C6C1; -.
DR   PeptideAtlas; P0C6C1; -.
DR   PRIDE; P0C6C1; -.
DR   ProteomicsDB; 41238; -.
DR   ProteomicsDB; 52326; -.
DR   Antibodypedia; 68063; 63 antibodies from 11 providers.
DR   DNASU; 390616; -.
DR   Ensembl; ENST00000421388.4; ENSP00000401089.2; ENSG00000235711.5.
DR   GeneID; 390616; -.
DR   KEGG; hsa:390616; -.
DR   MANE-Select; ENST00000421388.4; ENSP00000401089.2; NM_001146341.2; NP_001139813.1.
DR   UCSC; uc059mho.1; human.
DR   CTD; 390616; -.
DR   GeneCards; ANKRD34C; -.
DR   HGNC; HGNC:33888; ANKRD34C.
DR   HPA; ENSG00000235711; Tissue enriched (brain).
DR   neXtProt; NX_P0C6C1; -.
DR   OpenTargets; ENSG00000235711; -.
DR   VEuPathDB; HostDB:ENSG00000235711; -.
DR   eggNOG; ENOG502QW3G; Eukaryota.
DR   GeneTree; ENSGT00880000138051; -.
DR   HOGENOM; CLU_042805_0_0_1; -.
DR   InParanoid; P0C6C1; -.
DR   OMA; VACMSTH; -.
DR   OrthoDB; 466691at2759; -.
DR   PhylomeDB; P0C6C1; -.
DR   TreeFam; TF331155; -.
DR   PathwayCommons; P0C6C1; -.
DR   BioGRID-ORCS; 390616; 8 hits in 1058 CRISPR screens.
DR   GenomeRNAi; 390616; -.
DR   Pharos; P0C6C1; Tdark.
DR   PRO; PR:P0C6C1; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; P0C6C1; protein.
DR   Bgee; ENSG00000235711; Expressed in Brodmann (1909) area 23 and 66 other tissues.
DR   Genevisible; P0C6C1; HS.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR042637; AN34A/B/C.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24156; PTHR24156; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   3: Inferred from homology;
KW   ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..535
FT                   /note="Ankyrin repeat domain-containing protein 34C"
FT                   /id="PRO_0000319104"
FT   REPEAT          10..39
FT                   /note="ANK 1"
FT   REPEAT          43..80
FT                   /note="ANK 2"
FT   REPEAT          84..114
FT                   /note="ANK 3"
FT   REPEAT          118..147
FT                   /note="ANK 4"
FT   REGION          159..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          214..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          381..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..234
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..435
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         301
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BLB8"
FT   MOD_RES         447
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BLB8"
FT   VARIANT         369
FT                   /note="P -> R (in dbSNP:rs410400)"
FT                   /id="VAR_038953"
FT   VARIANT         427
FT                   /note="P -> H (in dbSNP:rs449340)"
FT                   /id="VAR_038954"
FT   VARIANT         442
FT                   /note="L -> I (in dbSNP:rs422777)"
FT                   /id="VAR_038955"
SQ   SEQUENCE   535 AA;  58256 MW;  8B2757427F9F3686 CRC64;
     MMDDDTELRT DGNSLLKAVW LGRLRLTRLL LEGGAYINES NDKGETALMV ACITKHVDQQ
     SISKSKMVKY LLDNRADPNI QDKSGKTALI HACIRRAGGE VVSLLLENGA DPSLEDRTGA
     SALVYAINAD DKDALKHLLD ACKAKGKEVI IITTDKSSSG TKTTKQYLNV PPSPKVEDRH
     SPPLCASPSD IELKALGLDS PLTEKEDDFF SLQAGHPSSC NTSKAVNEPG SPTRKVSNLK
     RARLPQLKRL QSEPWGLIAP SVLAASTRQD ETHGASTDNE VIKSISDISF PKRGPLSRTN
     SIDSKDPTLF HTVTEQVLKI PVSSAPASWK AAYEKGQAPH PRLARRGTLP VDQEKCGMGP
     SGPSALKEPA SLKWLENDLY DLDIQPGPDP PNSISLESGK GPLDRKKLNS SHLSLFHGSR
     ESLDTVPSTS PSSARRRPPH LLERRGSGTL LLDRISHTRP GFLPPLNVNL NPPIPDIRSS
     SKPSCSLASG LKSMVPVAPS SPKRVDLRSK KKLLRRHSMQ IEQMKQLSDF EEIMT
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024