ID   AN34C_MOUSE             Reviewed;         534 AA.
AC   Q8BLB8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Ankyrin repeat domain-containing protein 34C;
GN   Name=Ankrd34c;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301 AND SER-446, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the ANKRD34 family. {ECO:0000305}.
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DR   EMBL; AK045652; BAC32445.1; -; mRNA.
DR   CCDS; CCDS23397.1; -.
DR   RefSeq; NP_997143.1; NM_207260.2.
DR   RefSeq; XP_006511305.1; XM_006511242.3.
DR   RefSeq; XP_006511306.1; XM_006511243.3.
DR   AlphaFoldDB; Q8BLB8; -.
DR   SMR; Q8BLB8; -.
DR   STRING; 10090.ENSMUSP00000056787; -.
DR   iPTMnet; Q8BLB8; -.
DR   PhosphoSitePlus; Q8BLB8; -.
DR   PaxDb; Q8BLB8; -.
DR   PRIDE; Q8BLB8; -.
DR   ProteomicsDB; 281822; -.
DR   Antibodypedia; 68063; 63 antibodies from 11 providers.
DR   DNASU; 330998; -.
DR   Ensembl; ENSMUST00000060700; ENSMUSP00000056787; ENSMUSG00000047606.
DR   Ensembl; ENSMUST00000185470; ENSMUSP00000140919; ENSMUSG00000047606.
DR   GeneID; 330998; -.
DR   KEGG; mmu:330998; -.
DR   UCSC; uc009qzp.1; mouse.
DR   CTD; 390616; -.
DR   MGI; MGI:2685617; Ankrd34c.
DR   VEuPathDB; HostDB:ENSMUSG00000047606; -.
DR   eggNOG; ENOG502QW3G; Eukaryota.
DR   GeneTree; ENSGT00880000138051; -.
DR   HOGENOM; CLU_042805_0_0_1; -.
DR   InParanoid; Q8BLB8; -.
DR   OMA; VACMSTH; -.
DR   OrthoDB; 466691at2759; -.
DR   PhylomeDB; Q8BLB8; -.
DR   TreeFam; TF331155; -.
DR   BioGRID-ORCS; 330998; 2 hits in 71 CRISPR screens.
DR   PRO; PR:Q8BLB8; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q8BLB8; protein.
DR   Bgee; ENSMUSG00000047606; Expressed in epithelium of lens and 41 other tissues.
DR   ExpressionAtlas; Q8BLB8; baseline and differential.
DR   Genevisible; Q8BLB8; MM.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR042637; AN34A/B/C.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24156; PTHR24156; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   1: Evidence at protein level;
KW   ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..534
FT                   /note="Ankyrin repeat domain-containing protein 34C"
FT                   /id="PRO_0000319105"
FT   REPEAT          10..39
FT                   /note="ANK 1"
FT   REPEAT          43..80
FT                   /note="ANK 2"
FT   REPEAT          84..114
FT                   /note="ANK 3"
FT   REPEAT          118..147
FT                   /note="ANK 4"
FT   REGION          159..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          332..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          384..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          480..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         301
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         446
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   534 AA;  58171 MW;  54C971CDC3EBCE4A CRC64;
     MMDDDTELRT DGNSLLKAVW LGRLRLTRLL LEGGAYINES NDKGETALMV ACITKHVDQQ
     SISKSKMVKY LLDNRADPNI QDKSGKTALI HACIRRAGGE VVSLLLENGA DPSLEDRTGA
     SALVYAINAD DKDALKHLLD ACKAKGKEVI IITTDKSSSG TKTTKQYLNV PPSPKVEDRQ
     SPPLCTTPSD VELKTSGLAS PPSEKDDDFF ILQTGHQSGC STSKVLNEPG SPTRKVSSLK
     RARLPQLKRL QSEPWGLIAP SVLAAATRQD ETHGTSTDNE VIRSINDVTF PKRGPLSRTN
     SIDSKDPTLF PTVQEQVLKV SASTPASWKA AYEKGQAPHP RLARRGTLPL DQEKSGMCPP
     GPSTLKDPAS LKLLENDLYD LDIQPVGDPP NSMSLESGKG PLDRKKLNSS HLSLFHGSRE
     SLEVVPSTSP TSVRRRPPHL LERRGSGTLL LDRIAHTRPG FLPPLNVNLN PPIPDIRASS
     KPASPLASGL KSMAPVAPNS PKRVDLRSKK KLLRRHSMQI EQMKQLSDFE EIMA