AN36A_HUMAN
ID AN36A_HUMAN Reviewed; 1915 AA.
AC A6QL64; A0A494C0M0; B4E3I8; Q6UX02; Q86X62; Q9HCD1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2020, sequence version 4.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Ankyrin repeat domain-containing protein 36A;
GN Name=ANKRD36; Synonyms=ANKRD36A, KIAA1641; ORFNames=UNQ2430/PRO499;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=10997877; DOI=10.1093/dnares/7.4.271;
RA Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:273-281(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1414-1915 (ISOFORM 2).
RA Bruno R., d'Orlando O., Altomonte A., Lamaj E., Maio M., Pucillo C.;
RT "Study of the immune profile in metastatic melanoma patients immunized with
RT anti-idiotypic antibody by SEREX analysis.";
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=A6QL64-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6QL64-3; Sequence=VSP_039656, VSP_039661, VSP_039663,
CC VSP_039664, VSP_039665;
CC Name=3;
CC IsoId=A6QL64-4, Q6UX02-1;
CC Sequence=VSP_039657, VSP_039658;
CC Name=4;
CC IsoId=A6QL64-5, Q6UX02-2;
CC Sequence=VSP_039659, VSP_039660;
CC -!- SIMILARITY: Belongs to the ANKRD36 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ88934.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB13467.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB046861; BAB13467.1; ALT_INIT; mRNA.
DR EMBL; AY358571; AAQ88934.1; ALT_INIT; mRNA.
DR EMBL; AK304740; BAG65500.1; -; mRNA.
DR EMBL; AK316541; BAH14912.1; -; mRNA.
DR EMBL; AC018892; AAY14642.1; -; Genomic_DNA.
DR EMBL; AC160020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC046186; AAH46186.1; -; mRNA.
DR EMBL; BC146835; AAI46836.1; -; mRNA.
DR EMBL; AF543495; AAN40505.1; -; mRNA.
DR RefSeq; XP_006712577.1; XM_006712514.3. [A6QL64-1]
DR RefSeq; XP_011509432.1; XM_011511130.1.
DR RefSeq; XP_016859498.1; XM_017004009.1. [A6QL64-1]
DR AlphaFoldDB; A6QL64; -.
DR SMR; A6QL64; -.
DR BioGRID; 131962; 15.
DR IntAct; A6QL64; 2.
DR STRING; 9606.ENSP00000391950; -.
DR iPTMnet; A6QL64; -.
DR PhosphoSitePlus; A6QL64; -.
DR BioMuta; ANKRD36; -.
DR EPD; A6QL64; -.
DR jPOST; A6QL64; -.
DR MassIVE; A6QL64; -.
DR MaxQB; A6QL64; -.
DR PaxDb; A6QL64; -.
DR PeptideAtlas; A6QL64; -.
DR PRIDE; A6QL64; -.
DR ProteomicsDB; 1746; -. [A6QL64-1]
DR ProteomicsDB; 1747; -. [A6QL64-3]
DR Antibodypedia; 71228; 20 antibodies from 11 providers.
DR DNASU; 375248; -.
DR Ensembl; ENST00000420699.9; ENSP00000391950.4; ENSG00000135976.21. [A6QL64-1]
DR Ensembl; ENST00000461153.7; ENSP00000419530.3; ENSG00000135976.21. [A6QL64-1]
DR Ensembl; ENST00000652721.1; ENSP00000498611.1; ENSG00000135976.21. [A6QL64-1]
DR GeneID; 375248; -.
DR MANE-Select; ENST00000420699.9; ENSP00000391950.4; NM_001354587.1; NP_001341516.1.
DR UCSC; uc010yva.3; human. [A6QL64-1]
DR CTD; 375248; -.
DR DisGeNET; 375248; -.
DR GeneCards; ANKRD36; -.
DR HGNC; HGNC:24079; ANKRD36.
DR HPA; ENSG00000135976; Tissue enhanced (brain, retina).
DR neXtProt; NX_A6QL64; -.
DR OpenTargets; ENSG00000135976; -.
DR VEuPathDB; HostDB:ENSG00000135976; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000163264; -.
DR HOGENOM; CLU_001111_2_1_1; -.
DR InParanoid; A6QL64; -.
DR OMA; KTESEHN; -.
DR OrthoDB; 110145at2759; -.
DR PhylomeDB; A6QL64; -.
DR TreeFam; TF333496; -.
DR PathwayCommons; A6QL64; -.
DR SignaLink; A6QL64; -.
DR BioGRID-ORCS; 375248; 222 hits in 1009 CRISPR screens.
DR ChiTaRS; ANKRD36; human.
DR GenomeRNAi; 375248; -.
DR Pharos; A6QL64; Tdark.
DR PRO; PR:A6QL64; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; A6QL64; protein.
DR Bgee; ENSG00000135976; Expressed in corpus callosum and 101 other tissues.
DR ExpressionAtlas; A6QL64; baseline and differential.
DR Genevisible; A6QL64; HS.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039497; CC144C-like_CC_dom.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF14915; CCDC144C; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..1915
FT /note="Ankyrin repeat domain-containing protein 36A"
FT /id="PRO_0000334544"
FT REPEAT 31..60
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 64..93
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT REPEAT 97..126
FT /note="ANK 3"
FT /evidence="ECO:0000255"
FT REPEAT 130..159
FT /note="ANK 4"
FT /evidence="ECO:0000255"
FT REPEAT 163..192
FT /note="ANK 5"
FT /evidence="ECO:0000255"
FT REPEAT 196..225
FT /note="ANK 6"
FT /evidence="ECO:0000255"
FT REGION 261..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 639..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1285..1304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1489..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1383..1466
FT /evidence="ECO:0000255"
FT COILED 1504..1531
FT /evidence="ECO:0000255"
FT COILED 1573..1614
FT /evidence="ECO:0000255"
FT COILED 1727..1814
FT /evidence="ECO:0000255"
FT COMPBIAS 262..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..887
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..952
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..1020
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1057
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1095..1122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..1149
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10997877,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.6"
FT /id="VSP_039656"
FT VAR_SEQ 163
FT /note="C -> V (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_039657"
FT VAR_SEQ 164..1915
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_039658"
FT VAR_SEQ 164..170
FT /note="EYQPLLF -> LLRNNQP (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039659"
FT VAR_SEQ 171..1915
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039660"
FT VAR_SEQ 1150..1159
FT /note="DEQISGTVSC -> MYPFCFSVSS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10997877,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.6"
FT /id="VSP_039661"
FT VAR_SEQ 1293
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10997877,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.6"
FT /id="VSP_039663"
FT VAR_SEQ 1854..1866
FT /note="FQEIQDQLTATIR -> VCMQLCTPTTVNL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10997877,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.6"
FT /id="VSP_039664"
FT VAR_SEQ 1867..1915
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10997877,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.6"
FT /id="VSP_039665"
FT CONFLICT 1452
FT /note="V -> L (in Ref. 1; BAB13467 and 5; AAI46836)"
FT /evidence="ECO:0000305"
FT CONFLICT 1785
FT /note="N -> T (in Ref. 1; BAB13467 and 5; AAI46836)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1915 AA; 214500 MW; B2ED0D5A2EB0E955 CRC64;
MEDGKRERWP TLMERLCSDG FAFPQYPIKP YHLKRIHRAV LHGNLEKLKY LLLTYYDANK
RDRKERTALH LACATGQPEM VHLLVSRRCE LNLCDREDRT PLIKAVQLRQ EACATLLLQN
GANPNITDFF GRTALHYAVY NEDTSMIEKL LSHGTNIEEC SKCEYQPLLF AVSRRKVKMV
EFLLKKKANV NAIDYLGRSA LIHAVTLGEK DIVILLLQHN IDVLSRDAFR KIAGDYAIEA
KNRVIFDLIY EYERKRYEDL PINSNPVSSQ KQPALKATSG KEDSISNIAT EIKDGQKSGT
VSSQKQPALK DTSDKDDSVS NTATEIKDEQ KSGTVLPAVE QCLNRSLYRP DAVAQPVTEN
EFSLESEIIS KLYIPKRKII SPRSIKDVLP PVEEAVDRCL YLLDRFAQPV TKDKFALESE
NISEPYFTNR RTISQQSAEN LDAACGIDKT ENGNMFEDQN VDKEGKALPA TGQKANVSPE
QPPLFTHTVK DRDHISTRFL GGMDSLTSSE ESSERPPLST LTLKEADPSS KAAMRRKDSP
PPGKVSSQKQ PAEKATSDDK DSVSNIATEI KEGPISGTVS SQKQPAEKAT SDEKDSVSNI
ATEIKKGQQS GTVSPQKQSA WKVIFKKKVS LLNIATRIMG GGKSGTVSSQ KQPASKATSD
KTDSALNIAT EIKDGLQCGT VSSQKQPALK ATTDEEDSVS NIATEIKDGE KSGTVSSQKQ
PALKATTDEE DSVSNIATEI KDGEKSGTVS SQKQPALKAT TDEKDSVSNI ATEIKDGEKS
GTVSSQKPPA LTATSDEEGS VLSIARENKD GEKSRTVSSR KKPALKATSD EKDSFSNITR
GKKDGEISRK VSSQKPPTLK GTSDEEDSVL GIARENKDGE KSRTVSSEKP PGLKASSAEK
DSVLNIARGK KDGEKTKRVS SRKKPSLEAT SDEKDSFSNI TREKKDGEIS RKVSSQKPPA
LKGTSDEEDS VLGIARENKD GEKSRTVSSE KPPGLKATSD EKDSVLNIAR GKKDGEKTRT
VSSQKPPTLK ATSDEEDSVL SIARENKDGE KSRTVSSEKP SGLKATSAEK DSVLNIARGK
KYGEKTKRVS SRKKPALKAT SDEKDSVLYI AREKKDGEKS RTVSSPKQPA LKAICDKEDS
VPNMATEKKD EQISGTVSCQ KQPALKATSD KKDSVSNIPT EIKDGQQSGT VSSQKQPAWK
ATSVKKDSVS NIATEIKDGQ IRGTVSPQKQ SAQKVIFKKK VSLLNIATRI TGGWKSGTEY
PENLPTLKAT IENKNSVLNT ATKMKDVQTS TPAEQDLEMA SEGEQKRLEE YENNQPQVKN
QIHSRDDLDD IIQSSQTVSE DGDSLCCNCK NVILLIDQHE MKCKDCVHLL KIKNTFCLWK
RLIKLKDNHC EQLRVKIRKL KNKASVLQKR ISEKEEIKSQ LKHEILELEK ELCSLRFAIQ
QEKKKRRNVE EVHQKVREKL RITEEQYRIE ADVTKPIKPA LKSAEVELKT GGNNSNQVSE
TDEKEDLLHE NRLMQDEIAR LRLEKDTIKN QNLEKKYLKD FEIVKRKHED LQKALKRNGE
TLAKTIACYS GQLAALTDEN TTLRSKLEKQ RESRQRLETE MQSYHCRLNA ARCDHDQSHS
SKRDQELAFQ GTVDKCRHLQ ENLNSHVLIL SLQLSKAESK SRVLKTELHY TGEALKEKAL
VFEHVQSELK QKQSQMKDIE KMYKSGYNTM EKCIEKQERF CQLKKQNMLL QQQLDDARNK
ADNQEKAILN IQARCDARVQ NLQAECRKHR LLLEEDNKML VNELNHSKEK ECQYEKEKAE
REVAVRQLQQ KRDDVLNKGS ATKALLDASS RHCTYLENGM QDSRKKLDQM RSQFQEIQDQ
LTATIRCTKE MEGDTQKLEV EHVMMRKIIK KQDDQIERLE KILQHSSLML QVFES
