AN36B_HUMAN
ID AN36B_HUMAN Reviewed; 1353 AA.
AC Q8N2N9; Q08AK5; Q6IPR0; Q6PI49; Q8IZM7; Q8TDH6; Q96N30; Q9H759;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-AUG-2010, sequence version 4.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Ankyrin repeat domain-containing protein 36B;
DE AltName: Full=CLL-associated antigen KW-1;
GN Name=ANKRD36B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 435-884 AND 1204-1353 (ISOFORM 1).
RC TISSUE=Brain, Prostate, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1165-1353 (ISOFORM 3), AND NUCLEOTIDE SEQUENCE [LARGE
RP SCALE MRNA] OF 1204-1353 (ISOFORM 1).
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1120-1353 (ISOFORM 2).
RA Krackhardt A.M., Witzens M., Harig S., Hodi F.S., Zauls A.J., Chessia M.,
RA Barrett P., Gribben J.G.;
RT "Identification of novel tumor antigens in CLL by SEREX: assessment of
RT their potential as targets for immunotherapeutic approaches.";
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q8N2N9; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-2876112, EBI-10175124;
CC Q8N2N9-4; Q02040: AKAP17A; NbExp=3; IntAct=EBI-12170453, EBI-1042725;
CC Q8N2N9-4; Q8N2N9-4: ANKRD36B; NbExp=5; IntAct=EBI-12170453, EBI-12170453;
CC Q8N2N9-4; Q92997: DVL3; NbExp=3; IntAct=EBI-12170453, EBI-739789;
CC Q8N2N9-4; Q08426: EHHADH; NbExp=3; IntAct=EBI-12170453, EBI-2339219;
CC Q8N2N9-4; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-12170453, EBI-742102;
CC Q8N2N9-4; P55040: GEM; NbExp=3; IntAct=EBI-12170453, EBI-744104;
CC Q8N2N9-4; Q9BZE0: GLIS2; NbExp=3; IntAct=EBI-12170453, EBI-7251368;
CC Q8N2N9-4; Q8N8X9: MAB21L3; NbExp=3; IntAct=EBI-12170453, EBI-10268010;
CC Q8N2N9-4; P17568: NDUFB7; NbExp=3; IntAct=EBI-12170453, EBI-1246238;
CC Q8N2N9-4; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12170453, EBI-741158;
CC Q8N2N9-4; O00560: SDCBP; NbExp=3; IntAct=EBI-12170453, EBI-727004;
CC Q8N2N9-4; O75528: TADA3; NbExp=3; IntAct=EBI-12170453, EBI-473249;
CC Q8N2N9-4; Q8WVP5: TNFAIP8L1; NbExp=5; IntAct=EBI-12170453, EBI-752102;
CC Q8N2N9-4; Q99757: TXN2; NbExp=3; IntAct=EBI-12170453, EBI-2932492;
CC Q8N2N9-4; Q6F5E7: TXNRD3NB; NbExp=3; IntAct=EBI-12170453, EBI-18122152;
CC Q8N2N9-4; Q8TBK6: ZCCHC10; NbExp=3; IntAct=EBI-12170453, EBI-597063;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8N2N9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N2N9-2; Sequence=VSP_039668, VSP_039671;
CC Name=3;
CC IsoId=Q8N2N9-3; Sequence=VSP_039669, VSP_039670;
CC Name=4;
CC IsoId=Q8N2N9-4; Sequence=VSP_039666, VSP_039667;
CC -!- SIMILARITY: Belongs to the ANKRD36 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI25133.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI25134.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAL99915.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB15039.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB71081.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC017099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031883; AAH31883.1; -; mRNA.
DR EMBL; BC044844; AAH44844.1; -; mRNA.
DR EMBL; BC071771; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC125132; AAI25133.1; ALT_INIT; mRNA.
DR EMBL; BC125133; AAI25134.1; ALT_INIT; mRNA.
DR EMBL; AK024934; BAB15039.1; ALT_INIT; mRNA.
DR EMBL; AK056042; BAB71081.1; ALT_INIT; mRNA.
DR EMBL; AK074570; BAC11066.1; -; mRNA.
DR EMBL; AF432208; AAL99915.1; ALT_INIT; mRNA.
DR CCDS; CCDS74543.1; -. [Q8N2N9-1]
DR RefSeq; NP_079466.3; NM_025190.3. [Q8N2N9-1]
DR RefSeq; XP_005264052.1; XM_005263995.4. [Q8N2N9-1]
DR RefSeq; XP_006712724.1; XM_006712661.1. [Q8N2N9-1]
DR AlphaFoldDB; Q8N2N9; -.
DR SMR; Q8N2N9; -.
DR BioGRID; 121750; 60.
DR IntAct; Q8N2N9; 27.
DR STRING; 9606.ENSP00000481149; -.
DR iPTMnet; Q8N2N9; -.
DR PhosphoSitePlus; Q8N2N9; -.
DR BioMuta; ANKRD36B; -.
DR DMDM; 302393831; -.
DR EPD; Q8N2N9; -.
DR MassIVE; Q8N2N9; -.
DR MaxQB; Q8N2N9; -.
DR PeptideAtlas; Q8N2N9; -.
DR PRIDE; Q8N2N9; -.
DR Antibodypedia; 73249; 44 antibodies from 11 providers.
DR DNASU; 57730; -.
DR Ensembl; ENST00000258459.12; ENSP00000481149.1; ENSG00000196912.13. [Q8N2N9-1]
DR Ensembl; ENST00000359901.9; ENSP00000477778.1; ENSG00000196912.13. [Q8N2N9-1]
DR Ensembl; ENST00000443455.5; ENSP00000482644.1; ENSG00000196912.13. [Q8N2N9-4]
DR GeneID; 57730; -.
DR KEGG; hsa:57730; -.
DR MANE-Select; ENST00000359901.9; ENSP00000477778.1; NM_001393939.1; NP_001380868.1.
DR UCSC; uc010fid.2; human. [Q8N2N9-1]
DR CTD; 57730; -.
DR DisGeNET; 57730; -.
DR GeneCards; ANKRD36B; -.
DR HGNC; HGNC:29333; ANKRD36B.
DR HPA; ENSG00000196912; Tissue enhanced (bone).
DR neXtProt; NX_Q8N2N9; -.
DR OpenTargets; ENSG00000196912; -.
DR VEuPathDB; HostDB:ENSG00000196912; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000163264; -.
DR HOGENOM; CLU_001111_2_2_1; -.
DR InParanoid; Q8N2N9; -.
DR OMA; KHEIRET; -.
DR OrthoDB; 305292at2759; -.
DR PathwayCommons; Q8N2N9; -.
DR SignaLink; Q8N2N9; -.
DR BioGRID-ORCS; 57730; 0 hits in 128 CRISPR screens.
DR ChiTaRS; ANKRD36B; human.
DR GenomeRNAi; 57730; -.
DR Pharos; Q8N2N9; Tdark.
DR PRO; PR:Q8N2N9; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8N2N9; protein.
DR Bgee; ENSG00000196912; Expressed in sural nerve and 97 other tissues.
DR ExpressionAtlas; Q8N2N9; baseline and differential.
DR Genevisible; Q8N2N9; HS.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039497; CC144C-like_CC_dom.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF14915; CCDC144C; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..1353
FT /note="Ankyrin repeat domain-containing protein 36B"
FT /id="PRO_0000243912"
FT REPEAT 19..48
FT /note="ANK 1"
FT REPEAT 52..81
FT /note="ANK 2"
FT REPEAT 85..114
FT /note="ANK 3"
FT REPEAT 118..147
FT /note="ANK 4"
FT REPEAT 151..180
FT /note="ANK 5"
FT REPEAT 184..213
FT /note="ANK 6"
FT REGION 249..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 731..762
FT /evidence="ECO:0000255"
FT COILED 821..908
FT /evidence="ECO:0000255"
FT COILED 937..1055
FT /evidence="ECO:0000255"
FT COILED 1119..1344
FT /evidence="ECO:0000255"
FT COMPBIAS 262..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 233..239
FT /note="IFDLIYE -> VSSETTS (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_039666"
FT VAR_SEQ 240..1353
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_039667"
FT VAR_SEQ 1292..1304
FT /note="FQEIQDQLTATIR -> VCMQLCTPTTVNL (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_039668"
FT VAR_SEQ 1292
FT /note="F -> A (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039669"
FT VAR_SEQ 1293..1353
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039670"
FT VAR_SEQ 1305..1353
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_039671"
FT VARIANT 483
FT /note="E -> G (in dbSNP:rs1839230)"
FT /id="VAR_060687"
FT VARIANT 496
FT /note="E -> D (in dbSNP:rs13001728)"
FT /id="VAR_057818"
FT VARIANT 534
FT /note="S -> A (in dbSNP:rs6761299)"
FT /id="VAR_060688"
FT CONFLICT 3
FT /note="R -> C (in Ref. 3; BAC11066)"
FT /evidence="ECO:0000305"
FT CONFLICT 117
FT /note="V -> F (in Ref. 3; BAC11066)"
FT /evidence="ECO:0000305"
FT CONFLICT 884
FT /note="R -> K (in Ref. 2; AAH31883/AAH44844)"
FT /evidence="ECO:0000305"
FT CONFLICT 1223
FT /note="N -> T (in Ref. 3; BAB71081)"
FT /evidence="ECO:0000305"
FT CONFLICT 1310
FT /note="E -> D (in Ref. 3; BAB15039)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1353 AA; 153582 MW; B5EEB358EBBC0BE4 CRC64;
MERLCSDGFA FPHYYIKPYH LKRIHRAVLR GNLEKLKYLL LTYYDANKRD RKERTALHLA
CATGQPEMVH LLVSRRCELN LCDREDRTPL IKAVQLRQEA CATLLLQNGA DPNITDVFGR
TALHYAVYNE DTSMIEKLLS HGTNIEECSK NEYQPLLLAV SRRKVKMVEF LLKKKANVNA
IDYLGRSALI LAVTLGEKDI VILLLQHNID VFSRDVYGKL AEDYASEAEN RVIFDLIYEY
KRKRYEDLPI NSNPVSPQKQ RAEKATSDDK DSVSNIATEI KEGPISGTVS SQKQPAEKAT
SDEKDSVSNI ATEIKEGQQS GTVSPQKQSA QKVIFKKKVS LLNIATRIMG GGKSGTVSSQ
KQPASKTASD KTDSALNTAT EIKDGLQCGT VSSQKQQALK ATTDEEGSVS NIATEIKDGE
KSGTVSSQKK PALKATSDEK DSFSNITREK KDGEISRTVS SQKPPALKAT SVKEDSVLNI
AREKKDGEKS RTVSFEQPPG LKATRDEKDS LLNIARGKKD GEKTRRVSSH KQPSLKATSD
KEDSVPNMAT ETKDEQISGT VSCQKQPALK ATSDKKDSVS NIPTEIKDGQ QSGTVSSQKQ
PAWKATSVKK DSVSNIATEI KDGQIRGTVS SQRRPALKTT GDEKDSVSNI AREIKDGEKS
GTVSPQKQSA QKVIFKKKVS LLNIATRITG GGKSGTEYPE NLRTLKATIE NKDSVLNTAT
KMKEVQTSTP AEQDLEMASE GEQKRLEEYE NNQPQVKNQI HSRDDLDDII QSSQTVSEDG
DSLCCNCKNV ILLIDQHEMK CKDCVHLLKI KNTFCLWKRL IKLKDNHCEQ LRVKIRKLKN
KASVLQKRIS EKEEIKSQLK HEILELEKEL CSLRFAIQQE KKKRRNVEEL HQKVREKLRI
TEEQYRIEAD VTKPIKPALK SAEVELKTGG NNSNQVSETD EKEDLLHENR LMQDEIARLR
LEKDTIKNQN LEKKYLKDFE IVKRKHEDLQ KALKRNGETL AKTIACYSGQ LAALTDENTT
LRSKLEKQRE SRQRLETEMQ SYRCRLNAAR CDHDQSHSSK RDQELAFQGT VDKCRHLQEN
LNSHVLILSL QLSKAESKSR VLKTELHYTG EALKEKALVF EHVQSELKQK QSQMKDIEKM
YKSGYNTMEK CIEKQERFCQ LKKQNMLLQQ QLDDARNKAD NQEKAILNIQ ARCDARVQNL
QAECRKHRLL LEEDNKMLVN ELNHSKEKEC QYEKEKAERE VAVRQLQQKR DDVLNKGSAT
KALLDASSRH CTYLENGMQD SRKKLDQMRS QFQEIQDQLT ATIRCTKEME GDTQKLEVEH
VMMRKIIKKQ DDQIERLEKI LQHSSLMLQV FES
