AN36C_HUMAN
ID AN36C_HUMAN Reviewed; 1778 AA.
AC Q5JPF3; C9JZ08; Q15694; Q53S06; Q658V2;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-AUG-2010, sequence version 3.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Ankyrin repeat domain-containing protein 36C;
DE AltName: Full=Protein immuno-reactive with anti-PTH polyclonal antibodies;
GN Name=ANKRD36C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-1275 (ISOFORM 2).
RC TISSUE=Lymph node, and Stomach;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1418 (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 935-1305 (ISOFORM 1).
RX PubMed=8608414;
RA Kumar R., Haugen J.D., Wieben E.D., Londowski J.M., Cai Q.;
RT "Inhibitors of renal epithelial phosphate transport in tumor-induced
RT osteomalacia and uremia.";
RL Proc. Assoc. Am. Physicians 107:296-305(1995).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-829 AND SER-897, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5JPF3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5JPF3-2; Sequence=VSP_033675;
CC Name=3;
CC IsoId=Q5JPF3-3; Sequence=VSP_039672, VSP_039673, VSP_039674;
CC -!- SIMILARITY: Belongs to the ANKRD36 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB02177.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAB02177.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=AAY24080.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAH56324.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AL832977; CAH56324.1; ALT_SEQ; mRNA.
DR EMBL; AL832836; CAI46156.1; -; mRNA.
DR EMBL; AC013272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC073995; AAY24080.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK123626; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; U28831; AAB02177.1; ALT_SEQ; mRNA.
DR AlphaFoldDB; Q5JPF3; -.
DR SMR; Q5JPF3; -.
DR IntAct; Q5JPF3; 2.
DR STRING; 9606.ENSP00000403302; -.
DR iPTMnet; Q5JPF3; -.
DR PhosphoSitePlus; Q5JPF3; -.
DR BioMuta; ANKRD36C; -.
DR DMDM; 302393829; -.
DR EPD; Q5JPF3; -.
DR jPOST; Q5JPF3; -.
DR MassIVE; Q5JPF3; -.
DR MaxQB; Q5JPF3; -.
DR PaxDb; Q5JPF3; -.
DR PeptideAtlas; Q5JPF3; -.
DR PRIDE; Q5JPF3; -.
DR ProteomicsDB; 63012; -. [Q5JPF3-1]
DR ProteomicsDB; 63013; -. [Q5JPF3-2]
DR ProteomicsDB; 63014; -. [Q5JPF3-3]
DR Antibodypedia; 77805; 3 antibodies from 3 providers.
DR Ensembl; ENST00000456556.5; ENSP00000403302.1; ENSG00000174501.15. [Q5JPF3-1]
DR UCSC; uc061ltz.1; human. [Q5JPF3-1]
DR GeneCards; ANKRD36C; -.
DR HGNC; HGNC:32946; ANKRD36C.
DR HPA; ENSG00000174501; Tissue enhanced (brain).
DR neXtProt; NX_Q5JPF3; -.
DR OpenTargets; ENSG00000174501; -.
DR VEuPathDB; HostDB:ENSG00000174501; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000163264; -.
DR HOGENOM; CLU_001111_2_1_1; -.
DR InParanoid; Q5JPF3; -.
DR OMA; EKQPACK; -.
DR PhylomeDB; Q5JPF3; -.
DR TreeFam; TF333496; -.
DR PathwayCommons; Q5JPF3; -.
DR SignaLink; Q5JPF3; -.
DR ChiTaRS; ANKRD36C; human.
DR Pharos; Q5JPF3; Tdark.
DR PRO; PR:Q5JPF3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q5JPF3; protein.
DR Bgee; ENSG00000174501; Expressed in corpus callosum and 104 other tissues.
DR ExpressionAtlas; Q5JPF3; baseline and differential.
DR GO; GO:0008200; F:ion channel inhibitor activity; NAS:UniProtKB.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039497; CC144C-like_CC_dom.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF14915; CCDC144C; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; ANK repeat; Coiled coil; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..1778
FT /note="Ankyrin repeat domain-containing protein 36C"
FT /id="PRO_0000334545"
FT REPEAT 64..93
FT /note="ANK 1"
FT REPEAT 97..126
FT /note="ANK 2"
FT REPEAT 130..159
FT /note="ANK 3"
FT REPEAT 163..192
FT /note="ANK 4"
FT REPEAT 196..225
FT /note="ANK 5"
FT REGION 260..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1157..1187
FT /evidence="ECO:0000255"
FT COILED 1247..1333
FT /evidence="ECO:0000255"
FT COILED 1362..1480
FT /evidence="ECO:0000255"
FT COILED 1544..1768
FT /evidence="ECO:0000255"
FT COMPBIAS 262..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..883
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..1027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 829
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 897
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..973
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_033675"
FT VAR_SEQ 1..567
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_039672"
FT VAR_SEQ 1181..1185
FT /note="VKNQI -> IVFTY (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_039673"
FT VAR_SEQ 1186..1778
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_039674"
FT CONFLICT 1027
FT /note="L -> P (in Ref. 1; CAH56324/CAI46156, 3; AK123626
FT and 4; AAB02177)"
FT /evidence="ECO:0000305"
FT CONFLICT 1117
FT /note="G -> S (in Ref. 1; CAH56324/CAI46156 and 3;
FT AK123626)"
FT /evidence="ECO:0000305"
FT CONFLICT 1309
FT /note="R -> K (in Ref. 1; CAH56324)"
FT /evidence="ECO:0000305"
FT CONFLICT 1315
FT /note="L -> V (in Ref. 3; AK123626)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1778 AA; 199748 MW; 2E89BDBDCC7EDE5D CRC64;
MDDKEPKRWP TLRDRLCSDG FLFPQYPIKP YHLKGIHRAV FYRDLEELKF VLLTRYDINK
RDRKERTALH LACATGQPEM VHLLVSRRCE LNLCDREDRT PLIKAVQLRQ EACATLLLQN
GADPNITDVF GRTALHYAVY NEDTSMIEKL LSYGANIEEC SEDEYPPLFL AVSQRKVKMV
EFLLKKKANI NAVDYLGRSA LIHAVTLGEK DIVILLLQHN IDVFSRDVYG KLAEDYASEA
KNRVIFELIY EYERKKHEEL SINSNPVSSQ KQPALKATSG KEDSISNIAT EIKDGQKSGT
VSSQKQPALK GTSDKNDSVS NTATEIKDEQ KSGTVSSQKQ PALKDTSDKN DSVSNTATEI
KDEQKSGTVL PAVEQCLNRS LYRPDAVAQP VTEDEFALES EIISKLYIPK RKIISPRSIE
DVLPPVEEAV DRCLYLLDRF AQAVTKDKFA LESENISEPY FTNRRTISQQ SAEKLDAACG
IDKTENGTLF EDQNVDKEGK ALPATGQKAN VSPEQPPLFT HTVKDSDHIS TRFLGSMDSL
TSSEESSERP PLSTLTLKEA DPSSKAAMRR KDSPPPGKVS SQKQPAEKAT SDDKDSVSNI
ATEIKEGPIS GTVSSQKQPA EKATSDEKDS VSNIATEIKE GQQSGTVSPQ KQSAWKVIFK
KKVSLLNIAT RITGGGKSGT VSSQKQPPSK ATSDKTDSAL NIATEIKDGL QCGTVSSQKQ
PALKATTDEE DSVSNIATEI KDGEKSGTVS SQKQPALKAT TDEEDSVSII ATEIKDGEKS
GTVSSRKKPA LKATSDEKDS FSNITREKKD GEISRTVTSE KPAGLKATSD EEDSVLNIAR
GKEDGEKTRR VSSRKKPALK ATSDEKDSFS NITREKKDGE TSRTVSSQKP PALKATSDEE
DSVLNIAREK KDGEKSRTVS SEKPSGLKAT SDEKDSVLNI ARGKKHGEKT RRVSSHKQPA
LKATSDKENS VPNMATETKD EQISGTVSSQ KQPALKATSD KKDSVSNIPT EIKDGQQSGT
VSSQKQLAWK ATSVKKDSVS NIATEIKDGQ IRGTVSSQRQ PALKATGDEK DSVSNIAREI
KDGEKSGTVS PQKQSAQKVI FKKKVSLLNI ATRITGGWKS GTEYPENLPT LKATIENKNS
VLNTATKMKD VQTSTPEQDL EMASEGEQKR LEEYENNQPQ VKNQIHSRDD LDDIIQSSQT
VSEDGDSLCC NCKNVILLID QHEMKCKDCV HLLKIKKTFC LCKRLTELKD NHCEQLRVKI
RKLKNKASVL QKRLSEKEEI KSQLKHETLE LEKELCSLRF AIQQEKKKRR NVEELHQKVR
EKLRITEEQY RIEADVTKPI KPALKSAEVE LKTGGNNSNQ VSETDEKEDL LHENRLMQDE
IARLRLEKDT IKNQNLEKKY LKDFEIVKRK HEDLQKALKR NEETLAETIA CYSGQLAALT
DENTTLRSKL EKQRESGQRL ETEMQSYRCR LNAALCDHDQ SHSSKRDQEL AFQGTVDKCC
HLQENLNSHV LILSLQLSKA ESKFRVLETE LHYTGEALKE KALVFEHVQS ELKQKQSQMK
DIEKMYKSGY NTMEKCIEKQ ERFCQLKKQN MLLQQQLDDA RNKADNQEKA ILNIQARCDA
RVENLQAECR KHRLLLEEDN KMLVNELNHS KEKKCQYEKE KAEREVAVRQ LQQKQDDVLN
KRSATKALLD ASSRHCIYLE NGMQDSRKKL DQMRSQFQEI QDQLTATIRC TKEMEGDAQK
LEVENVMMRK IIKKQDEQIE RFEKILQHSS LMLQVFES
