ID   HBB_POGSC               Reviewed;         146 AA.
AC   P0C240;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Hemoglobin subunit beta;
DE   AltName: Full=Beta-globin;
DE   AltName: Full=Hemoglobin beta chain;
GN   Name=hbb;
OS   Pogonophryne scotti (Saddleback plunderfish) (Antarctic fish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Notothenioidei; Pogonophryne.
OX   NCBI_TaxID=36210;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=9829976; DOI=10.1074/jbc.273.49.32452;
RA   Tamburrini M., Romano M., Carratore V., Kunzmann A., Coletta M.,
RA   di Prisco G.;
RT   "The hemoglobins of the antarctic fishes Atedidraco orianae and
RT   Pogonophryne scotti. Amino acid sequence, lack of cooperativity, and ligand
RT   binding properties.";
RL   J. Biol. Chem. 273:32452-32459(1998).
CC   -!- FUNCTION: Involved in oxygen transport from gills to the various
CC       peripheral tissues.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   AlphaFoldDB; P0C240; -.
DR   SMR; P0C240; -.
DR   PRIDE; P0C240; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..146
FT                   /note="Hemoglobin subunit beta"
FT                   /id="PRO_0000260299"
FT   BINDING         63
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         92
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   146 AA;  16126 MW;  867AA043A57D0840 CRC64;
     VQWSESERTI INGIFSHLDY DDLGPKAFSR CLIVYPWTQR YFSSFGNLHN AEAIMGNANV
     AAHGIKVLHG LDLGLKHMDD IMGAYAELSS LHSEKLHVDP DNFKLLSDCI IIAVAAKLGN
     AFTPETQAAF HKFLAVVVSA LGKQYH