ID   HBB_PTEGI               Reviewed;         146 AA.
AC   D0VX08; P86192;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Hemoglobin subunit beta {ECO:0000250|UniProtKB:P14391};
DE   AltName: Full=Beta-globin {ECO:0000250|UniProtKB:P14391};
DE   AltName: Full=Hemoglobin beta chain {ECO:0000250|UniProtKB:P14391, ECO:0000312|PDB:3FH9};
GN   Name=HBB {ECO:0000250|UniProtKB:P14391};
OS   Pteropus giganteus (Indian flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=143291;
RN   [1] {ECO:0000305, ECO:0000312|PDB:3FH9}
RP   X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS).
RA   Moorthy P.S., Neelagandan K., Balasubramanian M., Thenmozhi M.,
RA   Ponnuswamy M.N.;
RT   "Crystal structure determination of Indian flying fox (Pteropus giganteus)
RT   at 1.62 A resolution.";
RL   Submitted (DEC-2008) to the PDB data bank.
CC   -!- FUNCTION: Involved in oxygen transport from the lung to the various
CC       peripheral tissues. {ECO:0000305}.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC       {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Red blood cells. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PDB; 3FH9; X-ray; 1.62 A; B=1-146.
DR   PDBsum; 3FH9; -.
DR   AlphaFoldDB; D0VX08; -.
DR   SMR; D0VX08; -.
DR   PRIDE; D0VX08; -.
DR   EvolutionaryTrace; D0VX08; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Heme; Iron; Metal-binding; Oxygen transport;
KW   Phosphoprotein; S-nitrosylation; Transport.
FT   CHAIN           1..146
FT                   /note="Hemoglobin subunit beta"
FT                   /id="PRO_0000398146"
FT   BINDING         63
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000305"
FT   BINDING         92
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000305"
FT   MOD_RES         1
FT                   /note="N-acetylvaline"
FT                   /evidence="ECO:0000250|UniProtKB:P02086"
FT   MOD_RES         12
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   MOD_RES         44
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   MOD_RES         59
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   MOD_RES         82
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   MOD_RES         93
FT                   /note="S-nitrosocysteine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   MOD_RES         144
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P68871"
FT   HELIX           5..15
FT                   /evidence="ECO:0007829|PDB:3FH9"
FT   TURN            20..22
FT                   /evidence="ECO:0007829|PDB:3FH9"
FT   HELIX           23..34
FT                   /evidence="ECO:0007829|PDB:3FH9"
FT   HELIX           36..45
FT                   /evidence="ECO:0007829|PDB:3FH9"
FT   HELIX           51..55
FT                   /evidence="ECO:0007829|PDB:3FH9"
FT   HELIX           58..74
FT                   /evidence="ECO:0007829|PDB:3FH9"
FT   HELIX           81..84
FT                   /evidence="ECO:0007829|PDB:3FH9"
FT   HELIX           86..94
FT                   /evidence="ECO:0007829|PDB:3FH9"
FT   HELIX           101..118
FT                   /evidence="ECO:0007829|PDB:3FH9"
FT   HELIX           119..121
FT                   /evidence="ECO:0007829|PDB:3FH9"
FT   HELIX           124..142
FT                   /evidence="ECO:0007829|PDB:3FH9"
FT   HELIX           143..145
FT                   /evidence="ECO:0007829|PDB:3FH9"
SQ   SEQUENCE   146 AA;  15937 MW;  FC0590DF35543643 CRC64;
     VHLSGEEKAA VTGLWGKVKV DEVGGEALGR LLVVYPWTQR FFDSFGDLSS ASAVMGNPKV
     KAHGKKVLDS FSEGLQHLDN LKGTFAKLSE LHCDKLHVDP ENFRLLGNVL VCVLARHFGK
     EFTPQVQAAY QKVVAGVANA LAHKYH