HBB_SALSA
ID HBB_SALSA Reviewed; 148 AA.
AC Q91473; Q91466; Q91468;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Hemoglobin subunit beta;
DE AltName: Full=Beta-globin;
DE AltName: Full=Hemoglobin beta chain;
GN Name=hbb;
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RX PubMed=8151712; DOI=10.1007/bf00175492;
RA Wagner A., Deryckere F., McMorrow T., Gannon F.;
RT "Tail-to-tail orientation of the Atlantic salmon alpha- and beta-globin
RT genes.";
RL J. Mol. Evol. 38:28-35(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8924215; DOI=10.1089/dna.1996.15.407;
RA McMorrow T., Wagner A., Deryckere F., Gannon F.;
RT "Structural organization and sequence analysis of the globin locus in
RT Atlantic salmon.";
RL DNA Cell Biol. 15:407-414(1996).
CC -!- FUNCTION: Involved in oxygen transport from gills to the various
CC peripheral tissues.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; X69958; CAA49580.1; -; mRNA.
DR EMBL; X97284; CAA65945.1; -; Genomic_DNA.
DR EMBL; X97286; CAA65948.1; -; Genomic_DNA.
DR PIR; S41625; S41625.
DR RefSeq; NP_001117138.1; NM_001123666.1.
DR AlphaFoldDB; Q91473; -.
DR SMR; Q91473; -.
DR GeneID; 100136576; -.
DR KEGG; sasa:100136576; -.
DR OrthoDB; 1370439at2759; -.
DR Proteomes; UP000087266; Chromosome ssa03.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..148
FT /note="Hemoglobin subunit beta"
FT /id="PRO_0000053102"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT VARIANT 87
FT /note="T -> S"
FT VARIANT 122
FT /note="T -> A"
FT VARIANT 137
FT /note="A -> S"
SQ SEQUENCE 148 AA; 16126 MW; B8F246A7547DF046 CRC64;
MVDWTDAERS AIVGLWGKIS VDEIGPQALA RLLIVSPWTQ RHFSTFGNLS TPAAIMGNPA
VAKHGKTVMH GLDRAVQNLD DIKNAYTALS VMHSEKLHVD PDNFRLLADC ITVCVAAKLG
PTVFSADIQE AFQKFLAVVV SALGRQYH
