HBD_ATEGE
ID HBD_ATEGE Reviewed; 147 AA.
AC P02044;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Hemoglobin subunit delta;
DE AltName: Full=Delta-globin;
DE AltName: Full=Hemoglobin delta chain;
GN Name=HBD;
OS Ateles geoffroyi (Black-handed spider monkey) (Geoffroy's spider monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Atelidae;
OC Atelinae; Ateles.
OX NCBI_TaxID=9509;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2833675; DOI=10.1093/oxfordjournals.molbev.a040474;
RA Spritz R.A., Giebel L.B.;
RT "The structure and evolution of the spider monkey delta-globin gene.";
RL Mol. Biol. Evol. 5:21-29(1988).
RN [2]
RP PROTEIN SEQUENCE OF 2-147.
RX PubMed=4999925; DOI=10.1007/bf00487132;
RA Boyer S.H., Crosby E.F., Noyes A.N., Fuller G.F., Leslie S.E.,
RA Donaldson L.J., Vrablik G.R., Schaefer E.W. Jr., Thurmon T.F.;
RT "Primate hemoglobins: some sequences and some proposals concerning the
RT character of evolution and mutation.";
RL Biochem. Genet. 5:405-448(1971).
CC -!- SUBUNIT: Heterotetramer of two delta chains and two alpha chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; M19061; AAB00793.1; -; Genomic_DNA.
DR PIR; A31523; HDMKP.
DR AlphaFoldDB; P02044; -.
DR SMR; P02044; -.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:4999925"
FT CHAIN 2..147
FT /note="Hemoglobin subunit delta"
FT /id="PRO_0000053162"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT VARIANT 7
FT /note="E -> K (in allelic sequence)"
FT VARIANT 10
FT /note="A -> S (in allelic sequence)"
FT VARIANT 70
FT /note="G -> D (in allelic sequence)"
FT CONFLICT 6
FT /note="P -> G (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 48
FT /note="D -> A (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 53
FT /note="A -> D (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 147 AA; 15933 MW; 7A7D16E6D313FA34 CRC64;
MVHLTPEEKA AVAALWGKVN VDEVGGEALG RLLVVYPWTQ RFFESFGDLS TPAAVMGNPK
VKAHGKKVLG AFSDGLAHLD NLKGTFAQLS ELHCDKLHVD PENFRLLGNV LVCVLARNFG
KEFTPQVQAA FQKVVAGVAT ALAHKYH
