ID   HBD_BRADU               Reviewed;         293 AA.
AC   Q45223;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=3-hydroxybutyryl-CoA dehydrogenase;
DE            EC=1.1.1.157;
DE   AltName: Full=Beta-hydroxybutyryl-CoA dehydrogenase;
DE            Short=BHBD;
GN   Name=hbdA; OrderedLocusNames=blr1379;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=USDA 3I1b110;
RA   Weidenhaupt M., Rossi P., Beck C., Fischer H.-M., Hennecke H.;
RL   Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(3S)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+)
CC         + NADPH; Xref=Rhea:RHEA:16197, ChEBI:CHEBI:15378, ChEBI:CHEBI:57286,
CC         ChEBI:CHEBI:57316, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         EC=1.1.1.157;
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U32229; AAB00905.1; -; Genomic_DNA.
DR   EMBL; BA000040; BAC46644.1; -; Genomic_DNA.
DR   RefSeq; NP_768019.1; NC_004463.1.
DR   RefSeq; WP_011084197.1; NZ_CP011360.1.
DR   AlphaFoldDB; Q45223; -.
DR   SMR; Q45223; -.
DR   STRING; 224911.27349630; -.
DR   EnsemblBacteria; BAC46644; BAC46644; BAC46644.
DR   GeneID; 64021248; -.
DR   KEGG; bja:blr1379; -.
DR   PATRIC; fig|224911.44.peg.801; -.
DR   eggNOG; COG1250; Bacteria.
DR   HOGENOM; CLU_009834_2_0_5; -.
DR   InParanoid; Q45223; -.
DR   OMA; FYDYSES; -.
DR   PhylomeDB; Q45223; -.
DR   UniPathway; UPA00863; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0019605; P:butyrate metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Lipid metabolism; NADP; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..293
FT                   /note="3-hydroxybutyryl-CoA dehydrogenase"
FT                   /id="PRO_0000109256"
FT   SITE            142
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   293 AA;  31716 MW;  0F388AD12E00D5B4 CRC64;
     MAAVIKKVGV IGAGQMGNGI AHVAALAGFD VVLNDVSADR LKSGMATING NLARQVSKKV
     VTEEAKTKAL SRIVAAEKLD DLADCDLVIE TAVEKEEVKR KIFHELCAVL KPEAIVASDT
     SSISITRLAA ATDRPERFIG IHFMNPVPLM ELVELIRGIA TDDATFEASK EFVAKLGKQV
     AVSEDFPAFI VNRILLPMIN EAIYTLYEGV GNVEAIDAAM KLGAHHPMGP LELADFIGLD
     TCLSIMQVLH EGLADSKYRP CPLLVKYVEA GWLGRKTQRG FYDYRGAKPV PTR