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HBD_DEIRA
ID   HBD_DEIRA               Reviewed;         278 AA.
AC   Q9RVG1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Probable 3-hydroxybutyryl-CoA dehydrogenase;
DE            EC=1.1.1.157;
DE   AltName: Full=Beta-hydroxybutyryl-CoA dehydrogenase;
DE            Short=BHBD;
GN   Name=hbd; OrderedLocusNames=DR_1068;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(3S)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+)
CC         + NADPH; Xref=Rhea:RHEA:16197, ChEBI:CHEBI:15378, ChEBI:CHEBI:57286,
CC         ChEBI:CHEBI:57316, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         EC=1.1.1.157;
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; AE000513; AAF10638.1; -; Genomic_DNA.
DR   PIR; B75442; B75442.
DR   RefSeq; NP_294792.1; NC_001263.1.
DR   RefSeq; WP_010887711.1; NZ_CP015081.1.
DR   AlphaFoldDB; Q9RVG1; -.
DR   SMR; Q9RVG1; -.
DR   STRING; 243230.DR_1068; -.
DR   EnsemblBacteria; AAF10638; AAF10638; DR_1068.
DR   KEGG; dra:DR_1068; -.
DR   PATRIC; fig|243230.17.peg.1264; -.
DR   eggNOG; COG1250; Bacteria.
DR   HOGENOM; CLU_009834_2_0_0; -.
DR   InParanoid; Q9RVG1; -.
DR   OMA; SVMEVFY; -.
DR   OrthoDB; 862072at2; -.
DR   UniPathway; UPA00863; -.
DR   Proteomes; UP000002524; Chromosome I.
DR   GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0019605; P:butyrate metabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Lipid metabolism; NADP; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..278
FT                   /note="Probable 3-hydroxybutyryl-CoA dehydrogenase"
FT                   /id="PRO_0000109261"
FT   SITE            136
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   278 AA;  30129 MW;  791C52B8C4A7C955 CRC64;
     MKFGVIGAGQ MGGGIAQVAA QSGFDVVVHD QKQEFLDRGK GVIEKSLGKL HEKGKLTDAP
     ETVLGRIHFT TDLQDFADCD LVVEAIVENQ QIKNDLFKQL GQIVKPEGIL ASNTSSIPIT
     ALATASGRPA QFIGMHFMNP VPLMQLVEVI RGYQTSDETA RIVTETAEKL GKTPLSCNDF
     PGFVSNRILM PMLNEAIQCV MEGVAEPEAI DGIMKLGMNH PMGPLTLADF IGLDTCLAIM
     EVLHQGLGDD KYRPSPLLRK MVQAGLLGRK SGEGFYKY
 
 
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