ID   HBD_OTOCR               Reviewed;         147 AA.
AC   Q03902;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Hemoglobin subunit delta;
DE   AltName: Full=Delta-globin;
DE   AltName: Full=Hemoglobin delta chain;
GN   Name=HBD;
OS   Otolemur crassicaudatus (Brown greater galago) (Galago crassicaudatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=9463;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2019578; DOI=10.1016/s0021-9258(20)89470-8;
RA   Tagle D.A., Slightom J.L., Jones R.T., Goodman M.;
RT   "Concerted evolution led to high expression of a prosimian primate delta
RT   globin gene locus.";
RL   J. Biol. Chem. 266:7469-7480(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=1639402; DOI=10.1016/0888-7543(92)90150-q;
RA   Tagle D.A., Stanhope M.J., Siemieniak D.R., Benson P.J., Goodman M.,
RA   Slightom J.L.;
RT   "The beta globin gene cluster of the prosimian primate Galago
RT   crassicaudatus: nucleotide sequence determination of the 41-kb cluster and
RT   comparative sequence analyses.";
RL   Genomics 13:741-760(1992).
CC   -!- SUBUNIT: Heterotetramer of two delta chains and two alpha chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; M61739; AAA35444.1; -; Genomic_DNA.
DR   EMBL; U60902; AAC50962.1; -; Genomic_DNA.
DR   PIR; A39733; A39733.
DR   AlphaFoldDB; Q03902; -.
DR   SMR; Q03902; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Oxygen transport; Phosphoprotein; Transport.
FT   CHAIN           1..147
FT                   /note="Hemoglobin subunit delta"
FT                   /id="PRO_0000053165"
FT   BINDING         64
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         93
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   MOD_RES         51
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02042"
SQ   SEQUENCE   147 AA;  16087 MW;  2AC698468D1ACB75 CRC64;
     MVHLTPDEKN AVCALWGKVN VEEVGGEALG RLLVVYPWTQ RFFDSFGDLS SPSAVMGNPK
     VKAHGKKVLS AFSEGLNHLD NLKGTFAKLS ELHCDKLHVD PENFRLLGNV LVVVLAHHFG
     KDFTPEVQAA YQKVVAGVAT ALAHKYH