HBD_PANTR
ID HBD_PANTR Reviewed; 147 AA.
AC P61772; P02043;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Hemoglobin subunit delta;
DE AltName: Full=Delta-globin;
DE AltName: Full=Hemoglobin delta chain;
GN Name=HBD;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11934441; DOI=10.1016/s0027-5107(02)00017-9;
RA Webster M.T., Wells R.S., Clegg J.B.;
RT "Analysis of variation in the human beta-globin gene cluster using a novel
RT DHPLC technique.";
RL Mutat. Res. 501:99-103(2002).
RN [2]
RP PROTEIN SEQUENCE OF 2-147.
RX PubMed=4999925; DOI=10.1007/bf00487132;
RA Boyer S.H., Crosby E.F., Noyes A.N., Fuller G.F., Leslie S.E.,
RA Donaldson L.J., Vrablik G.R., Schaefer E.W. Jr., Thurmon T.F.;
RT "Primate hemoglobins: some sequences and some proposals concerning the
RT character of evolution and mutation.";
RL Biochem. Genet. 5:405-448(1971).
RN [3]
RP PROTEIN SEQUENCE OF 2-147.
RX PubMed=5002785; DOI=10.1038/newbio234176a0;
RA de Jong W.W.W.;
RT "Structure of the delta-chain of chimpanzee haemoglobin A 2.";
RL Nature New Biol. 234:176-177(1971).
CC -!- SUBUNIT: Heterotetramer of two delta chains and two alpha chains.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; AF339363; AAL72101.1; -; Genomic_DNA.
DR PIR; C90233; HDCZ.
DR RefSeq; XP_001162045.2; XM_001162045.3.
DR AlphaFoldDB; P61772; -.
DR SMR; P61772; -.
DR STRING; 9598.ENSPTRP00000054849; -.
DR PaxDb; P61772; -.
DR Ensembl; ENSPTRT00000062293; ENSPTRP00000054849; ENSPTRG00000003238.
DR GeneID; 748577; -.
DR KEGG; ptr:748577; -.
DR CTD; 3045; -.
DR VGNC; VGNC:3253; HBD.
DR eggNOG; KOG3378; Eukaryota.
DR GeneTree; ENSGT00940000163476; -.
DR HOGENOM; CLU_003827_10_0_1; -.
DR InParanoid; P61772; -.
DR OMA; PKALCRC; -.
DR OrthoDB; 1370439at2759; -.
DR TreeFam; TF333268; -.
DR Proteomes; UP000002277; Chromosome 11.
DR Bgee; ENSPTRG00000003238; Expressed in bone marrow and 7 other tissues.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0031721; F:hemoglobin alpha binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Phosphoprotein; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:4999925,
FT ECO:0000269|PubMed:5002785"
FT CHAIN 2..147
FT /note="Hemoglobin subunit delta"
FT /id="PRO_0000053169"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT MOD_RES 51
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02042"
SQ SEQUENCE 147 AA; 16023 MW; F86BA4A08B56AB05 CRC64;
MVHLTPEEKT AVNALWGKVN VDAVGGEALG RLLVVYPWTQ RFFESFGDLS SPDAVMGNPK
VKAHGKKVLG AFSDGLAHLD NLKGTFSQLS ELHCDKLHVD PENFRLLGNV LVCVLARNFG
KEFTPQVQAA YQKVVAGVAN ALAHKYH
