ID   HBE1_CAPHI              Reviewed;         147 AA.
AC   P02102; Q28327;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Hemoglobin subunit epsilon-1;
DE   AltName: Full=Epsilon-1-globin;
DE   AltName: Full=Hemoglobin epsilon-1 chain;
DE   AltName: Full=Hemoglobin epsilon-I chain;
GN   Name=HBE1;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6312053; DOI=10.1016/s0022-2836(83)80174-0;
RA   Shapiro S.G., Schon E.A., Townes T.M., Lingrel J.B.;
RT   "Sequence and linkage of the goat epsilon I and epsilon II beta-globin
RT   genes.";
RL   J. Mol. Biol. 169:31-52(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-121.
RX   PubMed=6248519; DOI=10.1016/s0021-9258(18)43745-3;
RA   Haynes J.R., Rosteck P.R. Jr., Schon E.A., Gallagher P.M., Burks D.J.,
RA   Smith K., Lingrel J.B.;
RT   "The isolation of the beta A-, beta C-, and gamma-globin genes and a
RT   presumptive embryonic globin gene from a goat DNA recombinant library.";
RL   J. Biol. Chem. 255:6355-6367(1980).
CC   -!- FUNCTION: Beta-type chain found in early embryos.
CC   -!- SUBUNIT: Heterotetramer of two epsilon chains and two alpha chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; X01912; CAA25986.1; -; Genomic_DNA.
DR   EMBL; K00666; AAA30922.1; -; Genomic_DNA.
DR   EMBL; K00665; AAA30922.1; JOINED; Genomic_DNA.
DR   PIR; A02423; HEGT1.
DR   RefSeq; XP_005689868.1; XM_005689811.3.
DR   AlphaFoldDB; P02102; -.
DR   SMR; P02102; -.
DR   STRING; 9925.ENSCHIP00000030285; -.
DR   Ensembl; ENSCHIT00000038156; ENSCHIP00000030285; ENSCHIG00000024977.
DR   GeneID; 102174495; -.
DR   KEGG; chx:102174495; -.
DR   GeneTree; ENSGT00940000162659; -.
DR   OMA; INGLWSK; -.
DR   OrthoDB; 1370439at2759; -.
DR   Proteomes; UP000291000; Chromosome 15.
DR   Bgee; ENSCHIG00000024977; Expressed in testis.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT   CHAIN           1..147
FT                   /note="Hemoglobin subunit epsilon-1"
FT                   /id="PRO_0000053198"
FT   BINDING         64
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         93
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   CONFLICT        88
FT                   /note="K -> E (in Ref. 2; AAA30922)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        98
FT                   /note="H -> P (in Ref. 2; AAA30922)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        102..103
FT                   /note="EN -> LD (in Ref. 2; AAA30922)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        106..121
FT                   /note="LLGNVIVIILATHFGR -> ALGQCDCDYSGYSFWQ (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   147 AA;  16071 MW;  D30DC37E2EBC3F24 CRC64;
     MVHFTAEEKA AITGLWGKVN VEEAGGEALG RLLVVYPWTQ RFFDSFGNLS SASAIMGNPK
     VKAHGKKVLT SFGEAIKNLD NLKGAFAKLS ELHCDKLHVD PENFRLLGNV IVIILATHFG
     REFTPDVQAA WQKLVSGVAT ALAHKYH