ID   HBE2_CAPHI              Reviewed;         147 AA.
AC   P02105;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Hemoglobin subunit epsilon-2;
DE   AltName: Full=Epsilon-2-globin;
DE   AltName: Full=Hemoglobin epsilon-2 chain;
DE   AltName: Full=Hemoglobin epsilon-II chain;
GN   Name=HBE2;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6312053; DOI=10.1016/s0022-2836(83)80174-0;
RA   Shapiro S.G., Schon E.A., Townes T.M., Lingrel J.B.;
RT   "Sequence and linkage of the goat epsilon I and epsilon II beta-globin
RT   genes.";
RL   J. Mol. Biol. 169:31-52(1983).
CC   -!- FUNCTION: Beta-type chain found in early embryos.
CC   -!- SUBUNIT: Heterotetramer of two epsilon chains and two alpha chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X01913; CAA25987.1; ALT_SEQ; Genomic_DNA.
DR   PIR; A02426; HEGT2.
DR   AlphaFoldDB; P02105; -.
DR   SMR; P02105; -.
DR   STRING; 9925.ENSCHIP00000003296; -.
DR   Proteomes; UP000291000; Unassembled WGS sequence.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT   CHAIN           1..147
FT                   /note="Hemoglobin subunit epsilon-2"
FT                   /id="PRO_0000053199"
FT   BINDING         64
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         93
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   147 AA;  16405 MW;  1881DAFC106FB36C CRC64;
     MVHFTTEEKA AVASLWAKVN VEVVGGESLA RLLIVYPWTQ RFFDSFGNLC SESAIMGNPK
     VKAHGRKVLN SFGNAIKHMD DLKGTFADLS ELHCDKLHVD PPNFRLLGNM ILIVLATHFS
     KEFTPQMQAA WQKLTNAVAN ALAHKYH