HBE4_BOVIN
ID HBE4_BOVIN Reviewed; 147 AA.
AC P06643;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Hemoglobin subunit epsilon-4;
DE AltName: Full=Epsilon-4-globin;
DE AltName: Full=Hemoglobin epsilon-4 chain;
GN Name=HBE4;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3870873; DOI=10.1093/oxfordjournals.molbev.a040368;
RA Schimenti J.C., Duncan C.H.;
RT "Concerted evolution of the cow epsilon 2 and epsilon 4 beta-globin
RT genes.";
RL Mol. Biol. Evol. 2:505-513(1985).
CC -!- FUNCTION: Hemoglobin epsilon chain is a beta-type chain found in early
CC embryos.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X03249; CAA27008.1; -; Genomic_DNA.
DR PIR; B25754; HEBO4.
DR RefSeq; NP_001014910.1; NM_001014910.2.
DR AlphaFoldDB; P06643; -.
DR SMR; P06643; -.
DR STRING; 9913.ENSBTAP00000052791; -.
DR PaxDb; P06643; -.
DR Ensembl; ENSBTAT00000053566; ENSBTAP00000052791; ENSBTAG00000037751.
DR GeneID; 513108; -.
DR KEGG; bta:513108; -.
DR CTD; 513108; -.
DR VEuPathDB; HostDB:ENSBTAG00000037751; -.
DR eggNOG; KOG3378; Eukaryota.
DR GeneTree; ENSGT00940000164934; -.
DR HOGENOM; CLU_003827_10_0_1; -.
DR InParanoid; P06643; -.
DR OMA; YFAHFGN; -.
DR OrthoDB; 1370439at2759; -.
DR TreeFam; TF333268; -.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000037751; Expressed in infraspinatus muscle and 12 other tissues.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0031721; F:hemoglobin alpha binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT CHAIN 1..147
FT /note="Hemoglobin subunit epsilon-4"
FT /id="PRO_0000053183"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ SEQUENCE 147 AA; 16514 MW; B636CB5EAF354FEF CRC64;
MVHFTTEEKA AVASLWAKVN VEVVGGESLA RLLIVYPWTQ RFFDSFGNLY SESAIMGNPK
VKAHGRKVLN SFGNAIEHMD DLKGTFADLS ELHCDKLHVD PENFRLLGNM ILIVLATHFS
KEFTPQMQAS WQKLTNAVAN ALAHKYH
