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HBE4_BOVIN
ID   HBE4_BOVIN              Reviewed;         147 AA.
AC   P06643;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Hemoglobin subunit epsilon-4;
DE   AltName: Full=Epsilon-4-globin;
DE   AltName: Full=Hemoglobin epsilon-4 chain;
GN   Name=HBE4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3870873; DOI=10.1093/oxfordjournals.molbev.a040368;
RA   Schimenti J.C., Duncan C.H.;
RT   "Concerted evolution of the cow epsilon 2 and epsilon 4 beta-globin
RT   genes.";
RL   Mol. Biol. Evol. 2:505-513(1985).
CC   -!- FUNCTION: Hemoglobin epsilon chain is a beta-type chain found in early
CC       embryos.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; X03249; CAA27008.1; -; Genomic_DNA.
DR   PIR; B25754; HEBO4.
DR   RefSeq; NP_001014910.1; NM_001014910.2.
DR   AlphaFoldDB; P06643; -.
DR   SMR; P06643; -.
DR   STRING; 9913.ENSBTAP00000052791; -.
DR   PaxDb; P06643; -.
DR   Ensembl; ENSBTAT00000053566; ENSBTAP00000052791; ENSBTAG00000037751.
DR   GeneID; 513108; -.
DR   KEGG; bta:513108; -.
DR   CTD; 513108; -.
DR   VEuPathDB; HostDB:ENSBTAG00000037751; -.
DR   eggNOG; KOG3378; Eukaryota.
DR   GeneTree; ENSGT00940000164934; -.
DR   HOGENOM; CLU_003827_10_0_1; -.
DR   InParanoid; P06643; -.
DR   OMA; YFAHFGN; -.
DR   OrthoDB; 1370439at2759; -.
DR   TreeFam; TF333268; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000037751; Expressed in infraspinatus muscle and 12 other tissues.
DR   GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR   GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0031721; F:hemoglobin alpha binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR   GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR   GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR   GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT   CHAIN           1..147
FT                   /note="Hemoglobin subunit epsilon-4"
FT                   /id="PRO_0000053183"
FT   BINDING         64
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         93
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   147 AA;  16514 MW;  B636CB5EAF354FEF CRC64;
     MVHFTTEEKA AVASLWAKVN VEVVGGESLA RLLIVYPWTQ RFFDSFGNLY SESAIMGNPK
     VKAHGRKVLN SFGNAIEHMD DLKGTFADLS ELHCDKLHVD PENFRLLGNM ILIVLATHFS
     KEFTPQMQAS WQKLTNAVAN ALAHKYH
 
 
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