ID   ANC2_CAEEL              Reviewed;         731 AA.
AC   P34514; P34513;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 3.
DT   03-AUG-2022, entry version 161.
DE   RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000312|WormBase:K06H7.6};
DE            Short=APC2;
DE   AltName: Full=Cyclosome subunit 2;
GN   Name=apc-2 {ECO:0000312|WormBase:K06H7.6};
GN   ORFNames=K06H7.6/K06H7.5 {ECO:0000312|WormBase:K06H7.6};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=11861581; DOI=10.1093/genetics/160.2.805;
RA   Davis E.S., Wille L., Chestnut B.A., Sadler P.L., Shakes D.C., Golden A.;
RT   "Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex
RT   are required for chromosome segregation during meiosis I.";
RL   Genetics 160:805-813(2002).
CC   -!- FUNCTION: Probable component of the anaphase promoting
CC       complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that
CC       controls progression through mitosis and the G1 phase of the cell
CC       cycle. The APC/C complex acts by mediating ubiquitination and
CC       subsequent degradation of target proteins. Developmental role in early
CC       embryogenesis and the metaphase to anaphase transition in meiosis and
CC       mitosis. {ECO:0000269|PubMed:11861581}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305}.
CC   -!- SUBUNIT: The APC/C is probably composed of at least 12 subunits: apc-2,
CC       apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1, mat-2, mat-3,
CC       such-1 and gfi-3. {ECO:0000305}.
CC   -!- INTERACTION:
CC       P34514; Q20052: apc-11; NbExp=8; IntAct=EBI-321211, EBI-314913;
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in defective
CC       metaphase to anaphase transition (Mat phenotype) and embryos that
CC       arrest at the one-cell stage. {ECO:0000269|PubMed:11861581}.
CC   -!- SIMILARITY: Belongs to the cullin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00330}.
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DR   EMBL; BX284603; CCD64457.1; -; Genomic_DNA.
DR   PIR; S44845; S44845.
DR   PIR; S44846; S44846.
DR   RefSeq; NP_498762.2; NM_066361.5.
DR   AlphaFoldDB; P34514; -.
DR   SMR; P34514; -.
DR   BioGRID; 41345; 10.
DR   ComplexPortal; CPX-3382; Anaphase Promoting Complex/Cyclosome.
DR   IntAct; P34514; 4.
DR   STRING; 6239.K06H7.6; -.
DR   iPTMnet; P34514; -.
DR   EPD; P34514; -.
DR   PaxDb; P34514; -.
DR   PeptideAtlas; P34514; -.
DR   EnsemblMetazoa; K06H7.6.1; K06H7.6.1; WBGene00000143.
DR   GeneID; 176139; -.
DR   KEGG; cel:CELE_K06H7.6; -.
DR   UCSC; K06H7.6; c. elegans.
DR   CTD; 176139; -.
DR   WormBase; K06H7.6; CE41679; WBGene00000143; apc-2.
DR   eggNOG; KOG2165; Eukaryota.
DR   GeneTree; ENSGT00390000016127; -.
DR   HOGENOM; CLU_380467_0_0_1; -.
DR   InParanoid; P34514; -.
DR   OMA; FMYETFA; -.
DR   OrthoDB; 570797at2759; -.
DR   PhylomeDB; P34514; -.
DR   Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   SignaLink; P34514; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:P34514; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00000143; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IC:ComplexPortal.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR   GO; GO:0051445; P:regulation of meiotic cell cycle; IC:ComplexPortal.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IC:ComplexPortal.
DR   GO; GO:1904666; P:regulation of ubiquitin protein ligase activity; IC:ComplexPortal.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR044554; APC2-like.
DR   InterPro; IPR014786; APC2_C.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45957; PTHR45957; 1.
DR   Pfam; PF08672; ANAPC2; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   SMART; SM01013; APC2; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SUPFAM; SSF75632; SSF75632; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Developmental protein; Meiosis; Mitosis;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..731
FT                   /note="Anaphase-promoting complex subunit 2"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000119813"
SQ   SEQUENCE   731 AA;  84512 MW;  BFA67A3C39AC2BB4 CRC64;
     MSIFDRMTTS KEAAMKYRQF CVSKKKEVWD ALIYHAKYAK NIEKVYDMTT VLQRVQQECL
     MFALEKGVGQ PDIRDAAELI FPLAMQKVVI KVLRPYFMSH FTNYRLAMYL PHRKIDHGID
     LNQELWTPEK KEICGQYVQD FNPFVNELKT GILNANRHMN AALSVYIREL AATLVMHEKA
     AFDNELRCSM FQEIMESLRI WSDQVTMQDA FHLISDTIYK DVFQMLSKNA YEMIAVDFPV
     KFRSLITMKY CLLRTNNHGR VDFTNYLIDQ VNTKLLVASV DTKDILKAYA ACVESLREMD
     NSCVVMHKVC GVIREYLKRR PDTVQQIISY ITSNKKNELE KDMSLQSKTV RSAMMDEEEL
     KGVNDDFLPE NMETLGWENW MPNPTDATVG DGAPGHQGVD VFNMLVSVYG SKELFVKEYR
     NLLAERLSSS DNKDPEFEKR YLDLLKLRFQ YSELQHCEVM LRDVIHSLDI DKKFEDMSER
     SAGNYDVPII PISACIISSH YWPKLETEKT EALMPQPLQA AMDVYQETYL DVKRDRKLEW
     LRSVGCVEVS INIDGVEVDR TIPNMYALLL FLFLEKETWT TAEVVEKMGM SVVVTRKRLE
     WLVKQGFICM NPIISSDTWT LTRNPSGISI VRPGTPDLED DEDVEPEENS DMVDALEQYW
     GYTRNFIANH APNGEVKAER MHRVYRMFGS PTSAGPTLDH VSAFLQRKVA LGLLTCINGS
     YRIIQEKKDG E