ID   HBEAG_DHBV3             Reviewed;         305 AA.
AC   P0C6J9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=External core antigen;
DE   AltName: Full=HBeAg;
DE   AltName: Full=Precore protein;
DE   Flags: Precursor;
GN   Name=C;
OS   Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Avihepadnavirus.
OX   NCBI_TaxID=489542;
OH   NCBI_TaxID=8835; Anas (ducks).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3981148; DOI=10.1002/jmv.1890150402;
RA   Sprengel R., Kuhn C., Will H., Schaller H.;
RT   "Comparative sequence analysis of duck and human hepatitis B virus
RT   genomes.";
RL   J. Med. Virol. 15:323-333(1985).
CC   -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC       acting as a T-cell tolerogen, by having an immunoregulatory effect
CC       which prevents destruction of infected cells by cytotoxic T-cells.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimerizes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=External core antigen;
CC         IsoId=P0C6J9-1; Sequence=Displayed;
CC       Name=Capsid protein;
CC         IsoId=P0C6J8-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the avihepadnavirus precore antigen family.
CC       {ECO:0000305}.
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DR   EMBL; DQ195079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; P0C6J9; -.
DR   Proteomes; UP000007204; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.10.4090.10; -; 2.
DR   InterPro; IPR002006; Hepatitis_core.
DR   InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR   Pfam; PF00906; Hepatitis_core; 1.
DR   SUPFAM; SSF47852; SSF47852; 1.
PE   3: Inferred from homology;
KW   Alternative initiation; Host-virus interaction; Secreted; Signal;
KW   Viral immunoevasion.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..272
FT                   /note="External core antigen"
FT                   /id="PRO_0000324681"
FT   PROPEP          273..305
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000324682"
FT   REGION          226..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..263
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..278
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            272..273
FT                   /note="Cleavage; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   305 AA;  35010 MW;  AEA9F31CB1A29FBC CRC64;
     MWNLRITPLS FGAACQGIFT STLLLSCVTV PLVCTIVYDS CLYMDINASR ALANVYDLPD
     DFFPKIDDLV RDAKDALEPY WRSDSIKKHV LIATHFVDLI EDFWQTTQGM HEIAEALRAV
     IPPTTTPVPQ GYLIQHDEAE EIPLGDLFKH QEERIVSFQP DYPITARIHA HLKAYAKINE
     ESLDRARRLL WWHYNCLLWG EANVTNYISR LRTWLSTPER YRGRDAPTIE AITRPIQVAQ
     GGRKTTSGTR KPRGLEPRRR KVKTTVVYGR RRSKSRERRA PTPQRAGSPL PRSSSSHHRS
     PSPRK