HBEAG_HBVA3
ID HBEAG_HBVA3 Reviewed; 214 AA.
AC P0C625;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=External core antigen {ECO:0000255|HAMAP-Rule:MF_04076};
DE AltName: Full=HBeAg {ECO:0000255|HAMAP-Rule:MF_04076};
DE AltName: Full=Precore protein {ECO:0000255|HAMAP-Rule:MF_04076};
DE AltName: Full=p25 {ECO:0000255|HAMAP-Rule:MF_04076};
DE Flags: Precursor;
GN Name=C {ECO:0000255|HAMAP-Rule:MF_04076};
OS Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=480116;
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Valenzuela P., Quiroga M., Zaldivar J., Gray P., Rutter W.J.;
RT "The nucleotide sequence of the hepatitis B viral genome and the
RT identification of the major viral genes.";
RL (In) Field B.N., Jaenisch R., Fox C.F. (eds.);
RL Animal virus genetics, pp.57-70, Academic Press, New York (1980).
RN [2]
RP CLEAVAGE BY HOST.
RX PubMed=2657101; DOI=10.1128/jvi.63.6.2598-2604.1989;
RA Nassal M., Galle P.R., Schaller H.;
RT "Proteaselike sequence in hepatitis B virus core antigen is not required
RT for e antigen generation and may not be part of an aspartic acid-type
RT protease.";
RL J. Virol. 63:2598-2604(1989).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=2585603; DOI=10.1128/jvi.63.12.5238-5243.1989;
RA Ou J.H., Yeh C.T., Yen T.S.;
RT "Transport of hepatitis B virus precore protein into the nucleus after
RT cleavage of its signal peptide.";
RL J. Virol. 63:5238-5243(1989).
RN [4]
RP VARIANT LEU-126.
RX PubMed=10559327; DOI=10.1128/jvi.73.12.10122-10128.1999;
RA Yuan T.T., Tai P.C., Shih C.;
RT "Subtype-independent immature secretion and subtype-dependent replication
RT deficiency of a highly frequent, naturally occurring mutation of human
RT hepatitis B virus core antigen.";
RL J. Virol. 73:10122-10128(1999).
CC -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC acting as a T-cell tolerogen, by having an immunoregulatory effect
CC which prevents destruction of infected cells by cytotoxic T-cells. This
CC immune regulation may predispose to chronicity during perinatal
CC infections and prevent severe liver injury during adult infections.
CC {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- SUBUNIT: Homodimerizes. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|HAMAP-Rule:MF_04076,
CC ECO:0000269|PubMed:2585603}. Host nucleus {ECO:0000255|HAMAP-
CC Rule:MF_04076, ECO:0000269|PubMed:2585603}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=External core antigen;
CC IsoId=P0C625-1; Sequence=Displayed;
CC Name=Capsid protein;
CC IsoId=P03148-1; Sequence=External;
CC -!- PTM: Phosphorylated. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- PTM: Cleaved by host furin. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC {ECO:0000255|HAMAP-Rule:MF_04076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X02763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; P0C625; -.
DR Proteomes; UP000008766; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039619; C:T=4 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR GO; GO:0075521; P:microtubule-dependent intracellular transport of viral material towards nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.4090.10; -; 1.
DR HAMAP; MF_04076; HBV_HBEAG; 1.
DR InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR InterPro; IPR002006; Hepatitis_core.
DR InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR Pfam; PF08290; Hep_core_N; 1.
DR Pfam; PF00906; Hepatitis_core; 3.
DR SUPFAM; SSF47852; SSF47852; 1.
PE 1: Evidence at protein level;
KW Alternative initiation; Disulfide bond; Host nucleus;
KW Host-virus interaction; Repeat; Secreted; Signal; Viral immunoevasion.
FT SIGNAL 1..19
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT CHAIN 20..214
FT /note="External core antigen"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT /id="PRO_0000315013"
FT PROPEP 186..214
FT /evidence="ECO:0000250"
FT /id="PRO_0000314869"
FT REPEAT 186..192
FT /note="1; half-length"
FT REPEAT 193..200
FT /note="2"
FT REPEAT 201..208
FT /note="3"
FT REGION 25..27
FT /note="HBEAG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT REGION 165..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..208
FT /note="3 X 8 AA repeats of S-P-R-R-R-R-S-[PQ]"
FT COMPBIAS 182..204
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 185..186
FT /note="Cleavage; by host"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT DISULFID 77
FT /note="Interchain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT DISULFID 90
FT /note="Interchain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT VARIANT 122
FT /note="V -> M"
FT VARIANT 126
FT /note="I -> L (frequent mutation in chronic HBV carriers)"
FT /evidence="ECO:0000269|PubMed:10559327"
FT VARIANT 198
FT /note="R -> P"
SQ SEQUENCE 214 AA; 24580 MW; 56438263E63B46F6 CRC64;
MQLFHLCLII SCTCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPS DFFPSVRDLL
DTASALYREA LESPEHCSPH HTALRQAILC WGELMTLATW VGNNLEDPAS RDLVVNYVNT
NVGLKIRQLL WFHISCLTFG RETVLEYLVS FGVWIRTPPA YRPPNAPILS TLPETTVVRR
RDRGRSPRRR TPSPRRRRSP SPRRRRSQSR ESQC
