位置:首页 > 蛋白库 > HBEAG_HBVA6
HBEAG_HBVA6
ID   HBEAG_HBVA6             Reviewed;         214 AA.
AC   Q91C37;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=External core antigen {ECO:0000255|HAMAP-Rule:MF_04076};
DE   AltName: Full=HBeAg {ECO:0000255|HAMAP-Rule:MF_04076};
DE   AltName: Full=Precore protein {ECO:0000255|HAMAP-Rule:MF_04076};
DE   AltName: Full=p25 {ECO:0000255|HAMAP-Rule:MF_04076};
DE   Flags: Precursor;
GN   Name=C {ECO:0000255|HAMAP-Rule:MF_04076};
OS   Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001)
OS   (HBV-A).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=489454;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11596083; DOI=10.1002/jmv.2062.abs;
RA   Owiredu W.K., Kramvis A., Kew M.C.;
RT   "Molecular analysis of hepatitis B virus genomes isolated from black
RT   African patients with fulminant hepatitis B.";
RL   J. Med. Virol. 65:485-492(2001).
CC   -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC       acting as a T-cell tolerogen, by having an immunoregulatory effect
CC       which prevents destruction of infected cells by cytotoxic T-cells. This
CC       immune regulation may predispose to chronicity during perinatal
CC       infections and prevent severe liver injury during adult infections.
CC       {ECO:0000255|HAMAP-Rule:MF_04076}.
CC   -!- SUBUNIT: Homodimerizes. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|HAMAP-Rule:MF_04076}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04076}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=External core antigen;
CC         IsoId=Q91C37-1; Sequence=Displayed;
CC       Name=Capsid protein;
CC         IsoId=P0C695-1; Sequence=External;
CC   -!- PTM: Phosphorylated. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC   -!- PTM: Cleaved by host furin. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC   -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC       {ECO:0000255|HAMAP-Rule:MF_04076}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF297625; AAK97202.1; -; Genomic_DNA.
DR   PIR; C94409; NKVLA3.
DR   PIR; S33686; S33686.
DR   SMR; Q91C37; -.
DR   Proteomes; UP000007909; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039619; C:T=4 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0075521; P:microtubule-dependent intracellular transport of viral material towards nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.4090.10; -; 1.
DR   HAMAP; MF_04076; HBV_HBEAG; 1.
DR   InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR   InterPro; IPR002006; Hepatitis_core.
DR   InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR   Pfam; PF08290; Hep_core_N; 1.
DR   Pfam; PF00906; Hepatitis_core; 3.
DR   SUPFAM; SSF47852; SSF47852; 1.
PE   3: Inferred from homology;
KW   Alternative initiation; Disulfide bond; Host nucleus;
KW   Host-virus interaction; Repeat; Secreted; Signal; Viral immunoevasion.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT   CHAIN           20..214
FT                   /note="External core antigen"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT                   /id="PRO_0000324694"
FT   PROPEP          186..214
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000324695"
FT   REPEAT          186..192
FT                   /note="1; half-length"
FT   REPEAT          193..200
FT                   /note="2"
FT   REPEAT          201..208
FT                   /note="3"
FT   REGION          25..27
FT                   /note="HBEAG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT   REGION          165..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..208
FT                   /note="3 X 8 AA repeats of S-P-R-R-R-R-S-Q"
FT   COMPBIAS        182..204
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            185..186
FT                   /note="Cleavage; by host"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT   DISULFID        77
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT   DISULFID        90
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
SQ   SEQUENCE   214 AA;  24674 MW;  FA9EEEF3FC8C30CB CRC64;
     MQLFHLCLII SCTCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPS DFFPSVRDLL
     DTASALYREA LESPEHCSPH HTALRETILC WGELMTLATW VGNNLEDPAS RDLVVNYVNT
     NMGLKIRQLL WFHISCLTFG RETVLEYLVS FGVWIRTPPA YRPPNAPILS TLPETTVVRR
     RDRGRSPRRR TPSPRRRRSQ SPRRRRSQSR ESQC
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024