HBEAG_HBVA7
ID HBEAG_HBVA7 Reviewed; 214 AA.
AC O91532;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=External core antigen {ECO:0000255|HAMAP-Rule:MF_04076};
DE AltName: Full=HBeAg {ECO:0000255|HAMAP-Rule:MF_04076};
DE AltName: Full=Precore protein {ECO:0000255|HAMAP-Rule:MF_04076};
DE AltName: Full=p25 {ECO:0000255|HAMAP-Rule:MF_04076};
DE Flags: Precursor;
GN Name=C {ECO:0000255|HAMAP-Rule:MF_04076};
OS Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=489457;
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9930189; DOI=10.1007/s007050050463;
RA Takahashi K., Akahane Y., Hino K., Ohta Y., Mishiro S.;
RT "Hepatitis B virus genomic sequence in the circulation of hepatocellular
RT carcinoma patients: comparative analysis of 40 full-length isolates.";
RL Arch. Virol. 143:2313-2326(1998).
CC -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC acting as a T-cell tolerogen, by having an immunoregulatory effect
CC which prevents destruction of infected cells by cytotoxic T-cells. This
CC immune regulation may predispose to chronicity during perinatal
CC infections and prevent severe liver injury during adult infections.
CC {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- SUBUNIT: Homodimerizes. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|HAMAP-Rule:MF_04076}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=External core antigen;
CC IsoId=O91532-1; Sequence=Displayed;
CC Name=Capsid protein;
CC IsoId=P0C696-1; Sequence=External;
CC -!- PTM: Phosphorylated. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- PTM: Cleaved by host furin. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC {ECO:0000255|HAMAP-Rule:MF_04076}.
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DR EMBL; AB014370; BAA32870.1; -; Genomic_DNA.
DR PIR; C94409; NKVLA3.
DR PIR; S33686; S33686.
DR SMR; O91532; -.
DR Proteomes; UP000007910; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039619; C:T=4 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR GO; GO:0075521; P:microtubule-dependent intracellular transport of viral material towards nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.4090.10; -; 1.
DR HAMAP; MF_04076; HBV_HBEAG; 1.
DR InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR InterPro; IPR002006; Hepatitis_core.
DR InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR Pfam; PF08290; Hep_core_N; 1.
DR Pfam; PF00906; Hepatitis_core; 3.
DR SUPFAM; SSF47852; SSF47852; 1.
PE 3: Inferred from homology;
KW Alternative initiation; Disulfide bond; Host nucleus;
KW Host-virus interaction; Repeat; Secreted; Signal; Viral immunoevasion.
FT SIGNAL 1..19
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT CHAIN 20..214
FT /note="External core antigen"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT /id="PRO_0000324696"
FT PROPEP 186..214
FT /evidence="ECO:0000250"
FT /id="PRO_0000324697"
FT REPEAT 186..192
FT /note="1; half-length"
FT REPEAT 193..200
FT /note="2"
FT REPEAT 201..208
FT /note="3"
FT REGION 25..27
FT /note="HBEAG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT REGION 165..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..208
FT /note="3 X 8 AA repeats of S-P-R-R-R-R-S-Q"
FT COMPBIAS 182..204
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 185..186
FT /note="Cleavage; by host"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT DISULFID 77
FT /note="Interchain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT DISULFID 90
FT /note="Interchain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
SQ SEQUENCE 214 AA; 24685 MW; C6DB25353DD14953 CRC64;
MQLFHLCLII SCTCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPS DFFPSVRDLL
DTASALYREA LESPEHCSPH HTALRQAILC WVELMTLATW VGNNLQDPAS RDLVVNYVNT
NMGLKIRQLL WFHISCLTFG RETVLEYLVS FGVWIRTPPA YRPPNAPILS TLPETTVVRR
RDRGRSPRRR TPSPRRRRSQ SPRRRRSQSR ESQC
