HBEAG_HBVB1
ID HBEAG_HBVB1 Reviewed; 212 AA.
AC P0C699;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 1.
DT 03-AUG-2022, entry version 49.
DE RecName: Full=External core antigen {ECO:0000255|HAMAP-Rule:MF_04076};
DE AltName: Full=HBeAg {ECO:0000255|HAMAP-Rule:MF_04076};
DE AltName: Full=Precore protein {ECO:0000255|HAMAP-Rule:MF_04076};
DE AltName: Full=p25 {ECO:0000255|HAMAP-Rule:MF_04076};
DE Flags: Precursor;
GN Name=C {ECO:0000255|HAMAP-Rule:MF_04076};
OS Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988)
OS (HBV-B).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10413;
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3171552; DOI=10.1099/0022-1317-69-10-2575;
RA Okamoto H., Tsuda F., Sakugawa H., Sastrosoewignjo R.I., Imai M.,
RA Miyakawa Y., Mayumi M.;
RT "Typing hepatitis B virus by homology in nucleotide sequence: comparison of
RT surface antigen subtypes.";
RL J. Gen. Virol. 69:2575-2583(1988).
CC -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC acting as a T-cell tolerogen, by having an immunoregulatory effect
CC which prevents destruction of infected cells by cytotoxic T-cells. This
CC immune regulation may predispose to chronicity during perinatal
CC infections and prevent severe liver injury during adult infections.
CC {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- SUBUNIT: Homodimerizes. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|HAMAP-Rule:MF_04076}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=External core antigen;
CC IsoId=P0C699-1; Sequence=Displayed;
CC Name=Capsid protein;
CC IsoId=P17391-1; Sequence=External;
CC -!- PTM: Phosphorylated. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- PTM: Cleaved by host furin. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC {ECO:0000255|HAMAP-Rule:MF_04076}.
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DR EMBL; D00329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; P0C699; -.
DR Proteomes; UP000007913; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039619; C:T=4 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR GO; GO:0075521; P:microtubule-dependent intracellular transport of viral material towards nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.4090.10; -; 1.
DR HAMAP; MF_04076; HBV_HBEAG; 1.
DR InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR InterPro; IPR002006; Hepatitis_core.
DR InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR Pfam; PF08290; Hep_core_N; 1.
DR Pfam; PF00906; Hepatitis_core; 2.
DR SUPFAM; SSF47852; SSF47852; 1.
PE 3: Inferred from homology;
KW Alternative initiation; Disulfide bond; Host nucleus;
KW Host-virus interaction; Repeat; Secreted; Signal; Viral immunoevasion.
FT SIGNAL 1..19
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT CHAIN 20..212
FT /note="External core antigen"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT /id="PRO_0000324702"
FT PROPEP 184..212
FT /evidence="ECO:0000250"
FT /id="PRO_0000324703"
FT REPEAT 184..190
FT /note="1; half-length"
FT REPEAT 191..198
FT /note="2"
FT REPEAT 199..206
FT /note="3"
FT REGION 25..27
FT /note="HBEAG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT REGION 165..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..206
FT /note="3 X 8 AA repeats of S-P-R-R-R-R-S-Q"
FT COMPBIAS 181..202
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 183..184
FT /note="Cleavage; by host"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT DISULFID 77
FT /note="Interchain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT DISULFID 90
FT /note="Interchain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
SQ SEQUENCE 212 AA; 24444 MW; A8561E05E9A97032 CRC64;
MQLFHLCLVI SCSCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPS DFFPSVRDLL
DTVSALYREA LKSPEHCSPH HTALRQAILC WGELMTLATW VGNNLEDPAS RDLVVNYVNT
NMGLKIRQLW WFHISCLTFG RETVLEYLVS FGVWIRTPPA YRPPNAPILS TLPETTVVRR
RGRSPRRRTP SPRRRRSQSP RRRRSQSRES QC
