ID   HBEAG_HBVD2             Reviewed;          27 AA.
AC   P0C6H9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   29-SEP-2021, entry version 22.
DE   RecName: Full=Truncated HBeAg protein;
GN   Name=C;
OS   Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10411;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2345966; DOI=10.1016/0042-6822(90)90030-u;
RA   Tong S., Li J., Vitvitski L., Trepo C.;
RT   "Active hepatitis B virus replication in the presence of anti-HBe is
RT   associated with viral variants containing an inactive pre-C region.";
RL   Virology 176:596-603(1990).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=External core antigen;
CC         IsoId=P0C6H9-1; Sequence=Displayed;
CC       Name=Capsid protein;
CC         IsoId=P24023-1; Sequence=External;
CC   -!- MISCELLANEOUS: This virus has been isolated from a low active healthy
CC       carrier of HBV, negative for HBeAg. A genomic mutation in 1898 creates
CC       a stop codon at position 28 of HBeAg, without affecting capsid open
CC       reading frame. The HBeAg negative variants of HBV are associated with
CC       fulminant hepatitis, but can also be found in patients with persistent
CC       infection and chronic hepatitis.
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DR   EMBL; M32138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000007929; Genome.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR   Pfam; PF08290; Hep_core_N; 1.
PE   4: Predicted;
KW   Alternative initiation.
FT   CHAIN           1..27
FT                   /note="Truncated HBeAg protein"
FT                   /id="PRO_0000324723"
SQ   SEQUENCE   27 AA;  3009 MW;  B42B8A7F1C7B689D CRC64;
     MQLFHLCLII SCSCPTVQAS KLCLGWL