ID   HBEAG_HBVF1             Reviewed;         212 AA.
AC   Q05495;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=External core antigen {ECO:0000255|HAMAP-Rule:MF_04076};
DE   AltName: Full=HBeAg {ECO:0000255|HAMAP-Rule:MF_04076};
DE   AltName: Full=Precore protein {ECO:0000255|HAMAP-Rule:MF_04076};
DE   AltName: Full=p25 {ECO:0000255|HAMAP-Rule:MF_04076};
DE   Flags: Precursor;
GN   Name=C {ECO:0000255|HAMAP-Rule:MF_04076};
OS   Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=45410;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8345355; DOI=10.1099/0022-1317-74-8-1627;
RA   Naumann H., Schaefer S., Yoshida C.F.T., Gaspar A.M.C., Repp R.,
RA   Gerlich W.H.;
RT   "Identification of a new hepatitis B virus (HBV) genotype from Brazil that
RT   expresses HBV surface antigen subtype adw4.";
RL   J. Gen. Virol. 74:1627-1632(1993).
CC   -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC       acting as a T-cell tolerogen, by having an immunoregulatory effect
CC       which prevents destruction of infected cells by cytotoxic T-cells. This
CC       immune regulation may predispose to chronicity during perinatal
CC       infections and prevent severe liver injury during adult infections.
CC       {ECO:0000255|HAMAP-Rule:MF_04076}.
CC   -!- SUBUNIT: Homodimerizes. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|HAMAP-Rule:MF_04076}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04076}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=External core antigen;
CC         IsoId=Q05495-1; Sequence=Displayed;
CC       Name=Capsid protein;
CC         IsoId=P0C6I4-1; Sequence=External;
CC   -!- PTM: Phosphorylated. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC   -!- PTM: Cleaved by host furin. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC   -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC       {ECO:0000255|HAMAP-Rule:MF_04076}.
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DR   EMBL; X69798; CAA49452.1; -; Genomic_DNA.
DR   PIR; JQ2227; JQ2227.
DR   SMR; Q05495; -.
DR   Proteomes; UP000008284; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039619; C:T=4 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0075521; P:microtubule-dependent intracellular transport of viral material towards nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.4090.10; -; 1.
DR   HAMAP; MF_04076; HBV_HBEAG; 1.
DR   InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR   InterPro; IPR002006; Hepatitis_core.
DR   InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR   Pfam; PF08290; Hep_core_N; 1.
DR   Pfam; PF00906; Hepatitis_core; 3.
DR   SUPFAM; SSF47852; SSF47852; 1.
PE   3: Inferred from homology;
KW   Alternative initiation; Disulfide bond; Host nucleus;
KW   Host-virus interaction; Repeat; Secreted; Signal; Viral immunoevasion.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT   CHAIN           20..212
FT                   /note="External core antigen"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT                   /id="PRO_0000222321"
FT   PROPEP          184..212
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000324732"
FT   REPEAT          184..190
FT                   /note="1"
FT   REPEAT          191..198
FT                   /note="2"
FT   REPEAT          199..206
FT                   /note="3"
FT   REGION          25..27
FT                   /note="HBEAG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT   REGION          165..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          184..206
FT                   /note="3 X 8 AA repeats of S-P-R-R-R-R-S-Q"
FT   COMPBIAS        181..202
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            183..184
FT                   /note="Cleavage; by host"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT   DISULFID        77
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT   DISULFID        90
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
SQ   SEQUENCE   212 AA;  24234 MW;  F832610DB7C36FD2 CRC64;
     MQLFHLCLII FCSCPTVQAS KLCLGWLWGM DIDPYKEFGA SVELLSFLPS DFFPSVRDLL
     DTASALYRDA LESPEHCTPN HTALRQAILC WGELMTLASW VGNNLEDPAA RDLVVNYVNT
     NMGLKIRQLL WFHISCLTFG RETVLEYLVS FGVWIRTPPA YRPPNAPILS TLPETTVVRR
     RGRSPRRRTP SPRRRRSQSP RRRRSQSPAS QC