ID   HBEAG_HHBV              Reviewed;         305 AA.
AC   P13845;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=External core antigen;
DE   AltName: Full=HBeAg;
DE   AltName: Full=Precore protein;
DE   Flags: Precursor;
GN   Name=C;
OS   Heron hepatitis B virus (HHBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Avihepadnavirus.
OX   NCBI_TaxID=28300;
OH   NCBI_TaxID=8899; Ardeidae (herons).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3418788; DOI=10.1128/jvi.62.10.3832-3839.1988;
RA   Sprengel R., Kaleta E.F., Will H.;
RT   "Isolation and characterization of a hepatitis B virus endemic in herons.";
RL   J. Virol. 62:3832-3839(1988).
CC   -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC       acting as a T-cell tolerogen, by having an immunoregulatory effect
CC       which prevents destruction of infected cells by cytotoxic T-cells.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimerizes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=External core antigen;
CC         IsoId=P13845-1; Sequence=Displayed;
CC       Name=Capsid protein;
CC         IsoId=P0C6K0-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the avihepadnavirus precore antigen family.
CC       {ECO:0000305}.
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DR   EMBL; M22056; AAA45737.1; -; Genomic_DNA.
DR   PIR; C30082; NKVLHH.
DR   RefSeq; NP_040997.1; NC_001486.1. [P13845-1]
DR   SMR; P13845; -.
DR   GeneID; 2703544; -.
DR   KEGG; vg:2703544; -.
DR   Proteomes; UP000008679; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.10.4090.10; -; 2.
DR   InterPro; IPR002006; Hepatitis_core.
DR   InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR   Pfam; PF00906; Hepatitis_core; 1.
DR   SUPFAM; SSF47852; SSF47852; 1.
PE   3: Inferred from homology;
KW   Alternative initiation; Host-virus interaction; Secreted; Signal;
KW   Viral immunoevasion.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..272
FT                   /note="External core antigen"
FT                   /id="PRO_0000222307"
FT   PROPEP          273..305
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000324686"
FT   REGION          226..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..279
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..305
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            272..273
FT                   /note="Cleavage; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   305 AA;  34925 MW;  2B228EF44162CB06 CRC64;
     MWSLRLHPSP FGAACQGIFT STSLLFLVTV PLVCTIVYDS CLYMDVNASR ALANVYDLPD
     DFFPQIDDLV RDAKDALEPY WKAETIKKHV LIATHFVDLI EDFWQTTQGM SQIADALRAV
     IPPTTVPVPE GFLITHSEAE EIPLNDLFSN QEERIVNFQP DYPITARIHT HLRVYTKLNE
     QALDKARRLL WWHYNCLLWG EATVTNYISR LRTWLSTPEK YRGKDAPTIE AITRPIQVAQ
     GGRNQTKGTR KPRGLEPRRR KVKTTVVYGR RRSKSRGRRS SPSQRAGSPL PRNRGNQTRS
     PSPRE