HBEAG_HPBDC
ID HBEAG_HPBDC Reviewed; 305 AA.
AC P30027; E2QBU6;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=External core antigen;
DE AltName: Full=HBeAg;
DE AltName: Full=Precore protein;
DE Flags: Precursor;
GN Name=C;
OS Duck hepatitis B virus (strain China) (DHBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Avihepadnavirus.
OX NCBI_TaxID=31510;
OH NCBI_TaxID=8835; Anas (ducks).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2235506; DOI=10.1093/nar/18.20.6139;
RA Tong S., Mattes F., Teubner K., Blum H.E.;
RT "Complete nucleotide sequence of a Chinese duck hepatitis B virus.";
RL Nucleic Acids Res. 18:6139-6139(1990).
CC -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC acting as a T-cell tolerogen, by having an immunoregulatory effect
CC which prevents destruction of infected cells by cytotoxic T-cells.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimerizes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=External core antigen;
CC IsoId=P30027-1; Sequence=Displayed;
CC Name=Capsid protein;
CC IsoId=P0C6K1-1; Sequence=External;
CC -!- SIMILARITY: Belongs to the avihepadnavirus precore antigen family.
CC {ECO:0000305}.
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DR EMBL; M21953; AAA45744.1; -; Genomic_DNA.
DR SMR; P30027; -.
DR PRIDE; P30027; -.
DR Proteomes; UP000008119; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.10.4090.10; -; 2.
DR InterPro; IPR002006; Hepatitis_core.
DR InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR Pfam; PF00906; Hepatitis_core; 1.
DR SUPFAM; SSF47852; SSF47852; 1.
PE 3: Inferred from homology;
KW Alternative initiation; Host-virus interaction; Secreted; Signal;
KW Viral immunoevasion.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..272
FT /note="External core antigen"
FT /id="PRO_0000222303"
FT PROPEP 273..305
FT /evidence="ECO:0000250"
FT /id="PRO_0000324684"
FT REGION 226..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..278
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 272..273
FT /note="Cleavage; by host"
FT /evidence="ECO:0000250"
SQ SEQUENCE 305 AA; 34897 MW; 846D8938D785E1E2 CRC64;
MWNLRITPLS FGAACQGIFT STLLLSSLTV PLVCTIVYDS CLYMDINASR ALANVYDLPD
DFFPKIDDLV RDAKDALEPY WKSDSIKKHV LIATHFVDLI EDFWQTTQGM HEIAESLRAV
IPPTTAPVPT GYLIQHEEAE EIPLGDLFKH QEERIVSFQP DYPITARIHA HLKAYAKINE
ESLDRARRLL WWHYNCLLWG EANVTNYISR LRTWLSTPEK YRGRDAPTIE AITRPIQVAQ
GGRKTSSGTR KPRGLEPRRR KVKTTVVYGR RRSKSRERRA PSPQRAGSPL PRSSSSHHRS
PSPRK