HBEAG_WHV5
ID HBEAG_WHV5 Reviewed; 218 AA.
AC P0C6J6;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 1.
DT 03-AUG-2022, entry version 51.
DE RecName: Full=External core antigen {ECO:0000255|HAMAP-Rule:MF_04076};
DE AltName: Full=HBeAg {ECO:0000255|HAMAP-Rule:MF_04076};
DE AltName: Full=Precore protein {ECO:0000255|HAMAP-Rule:MF_04076};
DE AltName: Full=p25 {ECO:0000255|HAMAP-Rule:MF_04076};
DE Flags: Precursor;
GN Name=C {ECO:0000255|HAMAP-Rule:MF_04076};
OS Woodchuck hepatitis B virus (isolate 8) (WHV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10433;
OH NCBI_TaxID=9995; Marmota monax (Woodchuck).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Infectious clone;
RX PubMed=2928306; DOI=10.1073/pnas.86.6.1846;
RA Girones R., Cote P.J., Hornbuckle W.E., Tennant B.C., Gerin J.L.,
RA Purcell R.H., Miller R.H.;
RT "Complete nucleotide sequence of a molecular clone of woodchuck hepatitis
RT virus that is infectious in the natural host.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:1846-1849(1989).
CC -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC acting as a T-cell tolerogen, by having an immunoregulatory effect
CC which prevents destruction of infected cells by cytotoxic T-cells. This
CC immune regulation may predispose to chronicity during perinatal
CC infections and prevent severe liver injury during adult infections.
CC {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- SUBUNIT: Homodimerizes. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|HAMAP-Rule:MF_04076}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=External core antigen;
CC IsoId=P0C6J6-1; Sequence=Displayed;
CC Name=Capsid protein;
CC IsoId=P69711-1; Sequence=External;
CC -!- PTM: Phosphorylated. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- PTM: Cleaved by host furin. {ECO:0000255|HAMAP-Rule:MF_04076}.
CC -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC {ECO:0000255|HAMAP-Rule:MF_04076}.
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DR EMBL; J04514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; P0C6J6; -.
DR Proteomes; UP000000287; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039619; C:T=4 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR GO; GO:0075521; P:microtubule-dependent intracellular transport of viral material towards nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.4090.10; -; 1.
DR HAMAP; MF_04076; HBV_HBEAG; 1.
DR InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR InterPro; IPR002006; Hepatitis_core.
DR InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR Pfam; PF08290; Hep_core_N; 1.
DR Pfam; PF00906; Hepatitis_core; 3.
DR SUPFAM; SSF47852; SSF47852; 1.
PE 3: Inferred from homology;
KW Alternative initiation; Disulfide bond; Host nucleus;
KW Host-virus interaction; Repeat; Secreted; Signal; Viral immunoevasion.
FT SIGNAL 1..19
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT CHAIN 20..218
FT /note="External core antigen"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT /id="PRO_0000324748"
FT PROPEP 190..218
FT /evidence="ECO:0000250"
FT /id="PRO_0000324749"
FT REPEAT 190..196
FT /note="1; half-length"
FT REPEAT 197..204
FT /note="2"
FT REPEAT 205..212
FT /note="3"
FT REGION 26..28
FT /note="HBEAG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT REGION 180..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..212
FT /note="3 X 8 AA repeats of S-P-R-R-R-R-S-Q"
FT COMPBIAS 183..208
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 189..190
FT /note="Cleavage; by host"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT DISULFID 78
FT /note="Interchain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
FT DISULFID 91
FT /note="Interchain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04076"
SQ SEQUENCE 218 AA; 25124 MW; EE254B90C76D032C CRC64;
MYLFHLCLVF ACVPCPTFQA SKLCLGWLWG MDIDPYKEFG SSYQLLNFLP LDFFPDLNAL
VDTATALYEE ELTGREHCSP HHTAIRQALV CWDELTKLIA WMSSNITSEQ VRTIIVNHVN
DTWGLKVRQS LWFHLSCLTF GQHTVQEFLV SFGVWIRTPA PYRPPNAPIL STLPEHTVIR
RRGGARASRS PRRRTPSPRR RRSQSPRRRR SQSPSANC