ID   HBE_CAIMO               Reviewed;         147 AA.
AC   P14261;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Hemoglobin subunit epsilon;
DE   AltName: Full=Epsilon-globin;
DE   AltName: Full=Hemoglobin epsilon chain;
GN   Name=HBE;
OS   Cairina moschata (Muscovy duck).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Cairina.
OX   NCBI_TaxID=8855;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2362822; DOI=10.1093/nar/18.12.3657;
RA   Mathieu-Kolling C., Niessing J.;
RT   "Nucleotide sequence of the gene encoding the duck embryonic epsilon-
RT   globin.";
RL   Nucleic Acids Res. 18:3657-3657(1990).
CC   -!- FUNCTION: Beta-type chain found in early embryos.
CC   -!- SUBUNIT: Heterotetramer of two epsilon chains and two alpha chains.
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; X15740; CAA33757.1; -; Genomic_DNA.
DR   PIR; S14685; HEDKM.
DR   AlphaFoldDB; P14261; -.
DR   SMR; P14261; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Oxygen transport; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..147
FT                   /note="Hemoglobin subunit epsilon"
FT                   /id="PRO_0000053192"
FT   BINDING         64
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         93
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   147 AA;  16688 MW;  F720AB7FD8185394 CRC64;
     MVHWSAEEKQ LITGLWGKVN VEECGAEALA RLLIVYPWTQ RFFSSFGNLS SPTAIIGNPK
     VPPHGRKFFT SFGEPVKNLD NIKNTYAKLS ELHCEKLQVE PENFRLLGDI LIIVLASHFA
     RDFTPACQFP WQKLVSVVAH ALPRKYH