HBE_CHICK
ID HBE_CHICK Reviewed; 147 AA.
AC P02128;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Hemoglobin subunit epsilon;
DE AltName: Full=Epsilon-globin;
DE AltName: Full=Hemoglobin epsilon chain;
GN Name=HBE;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6313671; DOI=10.1016/s0021-9258(17)44230-x;
RA Dodgson J.B., Stadt S.J., Choi O.-R., Dolan M., Fischer H.D., Engel J.D.;
RT "The nucleotide sequence of the embryonic chicken beta-type globin genes.";
RL J. Biol. Chem. 258:12685-12692(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8307571; DOI=10.1016/s0888-7543(05)80364-7;
RA Reitman M., Grasso J.A., Blumenthal R., Lewit P.;
RT "Primary sequence, evolution, and repetitive elements of the Gallus gallus
RT (chicken) beta-globin cluster.";
RL Genomics 18:616-626(1993).
RN [3]
RP PROTEIN SEQUENCE OF 2-147.
RX PubMed=7054171; DOI=10.1016/s0021-9258(19)68241-4;
RA Chapman B.S., Hood L.E., Tobin A.J.;
RT "Amino acid sequences of the epsilon and alpha E globins of HbE, a minor
RT early embryonic hemoglobin of the chicken.";
RL J. Biol. Chem. 257:643-650(1982).
RN [4]
RP PROTEIN SEQUENCE OF 2-147.
RX PubMed=7054172; DOI=10.1016/s0021-9258(19)68242-6;
RA Chapman B.S., Hood L.E., Tobin A.J.;
RT "Minor early embryonic chick hemoglobin M. Amino acid sequences of the
RT epsilon and alpha D chains.";
RL J. Biol. Chem. 257:651-658(1982).
CC -!- FUNCTION: Beta-type chain found in early embryos.
CC -!- SUBUNIT: Heterotetramer of two epsilon chains and two alpha chains.
CC Hemoglobin E (Hbe) contains a alpha-A chains while hemoglobin M (Hbm)
CC contains alpha-D chains.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; K00824; AAA48807.1; -; Genomic_DNA.
DR EMBL; L17432; AAD03348.1; -; Genomic_DNA.
DR PIR; I50250; HECH.
DR RefSeq; NP_001075173.1; NM_001081704.1.
DR AlphaFoldDB; P02128; -.
DR SMR; P02128; -.
DR STRING; 9031.ENSGALP00000027976; -.
DR PaxDb; P02128; -.
DR GeneID; 107049060; -.
DR KEGG; gga:107049060; -.
DR CTD; 107049060; -.
DR VEuPathDB; HostDB:geneid_107049060; -.
DR eggNOG; KOG3378; Eukaryota.
DR InParanoid; P02128; -.
DR OrthoDB; 1370439at2759; -.
DR PhylomeDB; P02128; -.
DR PRO; PR:P02128; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:7054171,
FT ECO:0000269|PubMed:7054172"
FT CHAIN 2..147
FT /note="Hemoglobin subunit epsilon"
FT /id="PRO_0000053206"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT VARIANT 60
FT /note="R -> K"
SQ SEQUENCE 147 AA; 16603 MW; 4D905F656AA918E4 CRC64;
MVHWSAEEKQ LITSVWSKVN VEECGAEALA RLLIVYPWTQ RFFASFGNLS SPTAIMGNPR
VRAHGKKVLS SFGEAVKNLD NIKNTYAKLS ELHCDKLHVD PENFRLLGDI LIIVLASHFA
RDFTPACQFA WQKLVNVVAH ALARKYH
