HBE_DIDVI
ID HBE_DIDVI Reviewed; 147 AA.
AC P11025;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Hemoglobin subunit epsilon-M;
DE AltName: Full=Epsilon-M-globin;
DE AltName: Full=Hemoglobin epsilon-M chain;
GN Name=HBE1;
OS Didelphis virginiana (North American opossum) (Didelphis marsupialis
OS virginiana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Didelphis.
OX NCBI_TaxID=9267;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3375246; DOI=10.1073/pnas.85.11.3893;
RA Koop B., Goodman M.;
RT "Evolutionary and developmental aspects of two hemoglobin beta-chain genes
RT (epsilon M and beta M) of opossum.";
RL Proc. Natl. Acad. Sci. U.S.A. 85:3893-3897(1988).
CC -!- FUNCTION: Hemoglobin epsilon chain is a beta-type chain found in early
CC embryos.
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; J03642; AAA30977.1; -; Genomic_DNA.
DR PIR; A30213; A30213.
DR AlphaFoldDB; P11025; -.
DR SMR; P11025; -.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Metal-binding; Oxygen transport; Phosphoprotein; Transport.
FT CHAIN 1..147
FT /note="Hemoglobin subunit epsilon-M"
FT /id="PRO_0000053208"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT MOD_RES 14
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02100"
FT MOD_RES 51
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02100"
SQ SEQUENCE 147 AA; 16262 MW; 6354C7561F85CB22 CRC64;
MVHFTPEDKT NITSVWTKVD VEDVGGESLA RLLVVYPWTQ RFFDSFGNLS SASAVMGNPK
VKAHGKKVLT SFGEGVKNMD NLKGTFAKLS ELHCDKLHVD PENFRLLGNV LIIVLASRFG
KEFTPEVQAS WQKLVSGVSS ALGHKYH