HBE_MOUSE
ID HBE_MOUSE Reviewed; 147 AA.
AC P02104; Q62480; Q64358;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Hemoglobin subunit epsilon-Y2;
DE AltName: Full=Epsilon-Y2-globin;
DE AltName: Full=Hemoglobin epsilon-Y2 chain;
GN Name=Hbb-y;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/cJ;
RX PubMed=2926808; DOI=10.1016/0022-2836(89)90363-x;
RA Shehee W.R., Loeb D.D., Adey N.B., Burton F.H., Casavant N.C., Cole P.,
RA Davies C.J., McGraw R.A., Schichman S.A., Severynse D.M., Voliva C.F.,
RA Weyter F.W., Wisely G.B., Edgell M.H., Hutchison C.A. III;
RT "Nucleotide sequence of the BALB/c mouse beta-globin complex.";
RL J. Mol. Biol. 205:41-62(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/cJ;
RX PubMed=6274852; DOI=10.1016/s0021-9258(19)68306-7;
RA Hansen J.N., Konkel D.A., Leder P.;
RT "The sequence of a mouse embryonic beta-globin gene. Evolution of the gene
RT and its signal region.";
RL J. Biol. Chem. 257:1048-1052(1982).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RA Josifovska O., Gilman J.G.;
RL Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBA/CaJ; TISSUE=Embryo;
RX PubMed=2444404; DOI=10.1242/dev.99.4.493;
RA Wilkinson D.G., Bailes J.A., Champion J.E., McMahon A.P.;
RT "A molecular analysis of mouse development from 8 to 10 days post coitum
RT detects changes only in embryonic globin expression.";
RL Development 99:493-500(1987).
RN [5]
RP PROTEIN SEQUENCE OF 2-40.
RX PubMed=938477; DOI=10.1042/bj1550231;
RA Gilman J.G.;
RT "Mouse haemoglobin beta chains. Sequence data on embryonic y chain and
RT genetic linkage of the Y-chain locus to the adult beta-chain locus Hbb.";
RL Biochem. J. 155:231-241(1976).
RN [6]
RP NUCLEOTIDE SEQUENCE OF 22-147.
RX PubMed=6177582; DOI=10.1016/0378-1119(81)90070-6;
RA Vanin E.F., Farace M.G., Gambari R., Fantoni A.;
RT "The nucleotide sequence of the mouse embryonic beta-like y-globin
RT messenger RNA as determined from cloned cDNA.";
RL Gene 16:141-148(1981).
RN [7]
RP NUCLEOTIDE SEQUENCE OF 32-105.
RC STRAIN=BALB/cJ; TISSUE=Embryo;
RX PubMed=6250710; DOI=10.1016/0092-8674(80)90123-3;
RA Jahn C.L., Hutchison C.A. III, Phillips S.J., Weaver S., Haigwood N.L.,
RA Voliva C.F., Edgell M.H.;
RT "DNA sequence organization of the beta-globin complex in the BALB/c
RT mouse.";
RL Cell 21:159-168(1980).
CC -!- FUNCTION: Hemoglobin epsilon chain is a beta-type chain found in early
CC embryos.
CC -!- TISSUE SPECIFICITY: High expression in yolk sac blood islands, fetal
CC liver, and embryonic erythrocytes. Very low levels in adult liver and
CC spleen.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X14061; CAA32219.1; -; Genomic_DNA.
DR EMBL; V00726; CAA24104.1; -; Genomic_DNA.
DR EMBL; M95676; AAA40575.1; -; Genomic_DNA.
DR EMBL; M26897; AAA37701.1; -; mRNA.
DR EMBL; V00857; CAA24225.1; -; mRNA.
DR EMBL; V00742; CAA24117.1; -; Genomic_DNA.
DR CCDS; CCDS21593.1; -.
DR PIR; A92342; HEMSY2.
DR RefSeq; NP_032247.1; NM_008221.4.
DR AlphaFoldDB; P02104; -.
DR SMR; P02104; -.
DR BioGRID; 200224; 2.
DR ComplexPortal; CPX-2939; Embryonic hemoglobin complex.
DR STRING; 10090.ENSMUSP00000033229; -.
DR iPTMnet; P02104; -.
DR PhosphoSitePlus; P02104; -.
DR jPOST; P02104; -.
DR MaxQB; P02104; -.
DR PaxDb; P02104; -.
DR PeptideAtlas; P02104; -.
DR PRIDE; P02104; -.
DR ProteomicsDB; 271493; -.
DR DNASU; 15135; -.
DR GeneID; 15135; -.
DR KEGG; mmu:15135; -.
DR CTD; 15135; -.
DR MGI; MGI:96027; Hbb-y.
DR eggNOG; KOG3378; Eukaryota.
DR InParanoid; P02104; -.
DR OrthoDB; 1370439at2759; -.
DR PhylomeDB; P02104; -.
DR BioGRID-ORCS; 15135; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Hbb-y; mouse.
DR PRO; PR:P02104; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P02104; protein.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; ISO:MGI.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0031721; F:hemoglobin alpha binding; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0015670; P:carbon dioxide transport; IC:ComplexPortal.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:MGI.
DR GO; GO:0015671; P:oxygen transport; ISO:MGI.
DR GO; GO:0010942; P:positive regulation of cell death; IC:ComplexPortal.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Phosphoprotein; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:938477"
FT CHAIN 2..147
FT /note="Hemoglobin subunit epsilon-Y2"
FT /id="PRO_0000053219"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT MOD_RES 51
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02100"
FT VARIANT 22..23
FT /note="EE -> GK"
FT VARIANT 40
FT /note="Q -> H"
FT VARIANT 94
FT /note="Missing"
FT VARIANT 124
FT /note="Missing"
SQ SEQUENCE 147 AA; 16137 MW; BAA84E91B8864C88 CRC64;
MVNFTAEEKT LINGLWSKVN VEEVGGEALG RLLVVYPWTQ RFFDSFGNLS SASAIMGNPR
VKAHGKKVLT AFGESIKNLD NLKSALAKLS ELHCDKLHVD PENFKLLGNV LVIVLASHFG
NEFTAEMQAA WQKLVAGVAT ALSHKYH
