HBG_ATEGE
ID HBG_ATEGE Reviewed; 147 AA.
AC P68068; P06891;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Hemoglobin subunit gamma;
DE AltName: Full=Gamma-globin;
DE AltName: Full=Hemoglobin gamma chain;
GN Name=HBG;
OS Ateles geoffroyi (Black-handed spider monkey) (Geoffroy's spider monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Atelidae;
OC Atelinae; Ateles.
OX NCBI_TaxID=9509;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2413451; DOI=10.1073/pnas.82.20.6985;
RA Giebel L.B., van Santen V.L., Slightom J.L., Spritz R.A.;
RT "Nucleotide sequence, evolution, and expression of the fetal globin gene of
RT the spider monkey Ateles geoffroyi.";
RL Proc. Natl. Acad. Sci. U.S.A. 82:6985-6989(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1908094; DOI=10.1073/pnas.88.16.7396;
RA Fitch D.H., Bailey W.J., Tagle D.A., Goodman M., Sieu L., Slightom J.L.;
RT "Duplication of the gamma-globin gene mediated by L1 long interspersed
RT repetitive elements in an early ancestor of simian primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:7396-7400(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10222158; DOI=10.1006/mpev.1998.0574;
RA Meireles C.M., Czelusniak J., Schneider M.P.C., Muniz J.A.P.C.,
RA Brigido M.C., Ferreira H.S., Goodman M.;
RT "Molecular phylogeny of ateline new world monkeys (Platyrrhini, atelinae)
RT based on gamma-globin gene sequences: evidence that Brachyteles is the
RT sister group of Lagothrix.";
RL Mol. Phylogenet. Evol. 12:10-30(1999).
CC -!- FUNCTION: Gamma chains make up the fetal hemoglobin F, in combination
CC with alpha chains.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two gamma chains in
CC fetal hemoglobin (Hb F).
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; M36773; AAA36926.1; -; Genomic_DNA.
DR EMBL; X53420; CAA37499.1; -; Genomic_DNA.
DR EMBL; AF030092; AAB92226.1; -; Genomic_DNA.
DR PIR; S21892; HGMKS.
DR AlphaFoldDB; P68068; -.
DR SMR; P68068; -.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Metal-binding; Oxygen transport; Transport.
FT CHAIN 1..147
FT /note="Hemoglobin subunit gamma"
FT /id="PRO_0000053237"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ SEQUENCE 147 AA; 15940 MW; 8DFA15C6D043FA17 CRC64;
MSNFTAEDKA AITSLWGKVN VEDAGGETLG RLLVVYPWTQ RFFDSFGSLS SPSAIMGNPK
VKAHGVKVLT SLGEAIKNLD DLKGTFGQLS ELHCDKLHVD PENFRLLGNV LVTVLAILHG
KEFTPEVQAS WQKMVAGVAS ALASRYH
