HBG_CALJA
ID HBG_CALJA Reviewed; 147 AA.
AC Q9GJS7;
DT 25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Hemoglobin subunit gamma;
DE AltName: Full=Gamma-globin;
DE AltName: Full=Hemoglobin gamma chain;
GN Name=HBG1;
GN and
GN Name=HBG2;
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9461379; DOI=10.1016/s0378-1119(97)00476-9;
RA Chiu C.-H., Schneider H., Slightom J.L., Gumucio D.L., Goodman M.;
RT "Dynamics of regulatory evolution in primate beta-globin gene clusters:
RT cis-mediated acquisition of simian gamma fetal expression patterns.";
RL Gene 205:47-57(1997).
CC -!- FUNCTION: Gamma chains make up the fetal hemoglobin F, in combination
CC with alpha chains.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two gamma chains in
CC fetal hemoglobin (Hb F).
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; AF321384; AAG35074.1; -; Genomic_DNA.
DR EMBL; AF016991; AAG33930.1; -; Genomic_DNA.
DR RefSeq; XP_009005812.1; XM_009007564.1.
DR RefSeq; XP_009005813.1; XM_009007565.1.
DR AlphaFoldDB; Q9GJS7; -.
DR SMR; Q9GJS7; -.
DR STRING; 9483.ENSCJAP00000037571; -.
DR Ensembl; ENSCJAT00000039674; ENSCJAP00000037558; ENSCJAG00000020214.
DR Ensembl; ENSCJAT00000039678; ENSCJAP00000037562; ENSCJAG00000020214.
DR GeneID; 100388732; -.
DR GeneID; 100389093; -.
DR KEGG; cjc:100388732; -.
DR KEGG; cjc:100389093; -.
DR eggNOG; KOG3378; Eukaryota.
DR GeneTree; ENSGT00940000163476; -.
DR HOGENOM; CLU_003827_10_0_1; -.
DR InParanoid; Q9GJS7; -.
DR OrthoDB; 1370439at2759; -.
DR Proteomes; UP000008225; Chromosome 11.
DR Bgee; ENSCJAG00000020208; Expressed in heart and 5 other tissues.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT CHAIN 1..147
FT /note="Hemoglobin subunit gamma"
FT /id="PRO_0000053241"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ SEQUENCE 147 AA; 15980 MW; 8A6417F8C5F2FB17 CRC64;
MSNFTAEDKA AITSLWAKVN VEDAGGETLG RLLVVYPWTQ RFFDSFGSLS SPSAIMGNPK
VKAHGVKVLT SLGEAIKNLD DLKGTFGQLS ELHCDKLHVD PENFRLLGNV LVTVLAILYG
KEFTPEVQAS WQKMVAGVAS ALASRYH
