HBG_MACMU
ID HBG_MACMU Reviewed; 147 AA.
AC P68077; P02098;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Hemoglobin subunit gamma;
DE AltName: Full=Gamma-globin;
DE AltName: Full=Hemoglobin gamma chain;
GN Name=HBG;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3410846; DOI=10.1016/s0021-9258(18)37773-1;
RA Slightom J.L., Koop B.F., Xu P., Goodman M.;
RT "Rhesus fetal globin genes. Concerted gene evolution in the descent of
RT higher primates.";
RL J. Biol. Chem. 263:12427-12438(1988).
RN [2]
RP PROTEIN SEQUENCE OF 2-147.
RX PubMed=6157408; DOI=10.1021/bi00560a009;
RA Mahoney W.C., Nute P.E.;
RT "Fetal hemoglobin of the rhesus monkey, Macaca mulatta: complete primary
RT structure of the gamma chain.";
RL Biochemistry 19:4436-4442(1980).
CC -!- FUNCTION: Gamma chains make up the fetal hemoglobin F, in combination
CC with alpha chains.
CC -!- SUBUNIT: Heterotetramer of two alpha chains and two gamma chains in
CC fetal hemoglobin (Hb F).
CC -!- TISSUE SPECIFICITY: Red blood cells.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; M19434; AAA36846.1; -; Genomic_DNA.
DR PIR; A31109; HGMQR.
DR AlphaFoldDB; P68077; -.
DR SMR; P68077; -.
DR STRING; 9544.ENSMMUP00000031232; -.
DR eggNOG; KOG3378; Eukaryota.
DR InParanoid; P68077; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0031721; F:hemoglobin alpha binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR CDD; cd08925; Hb-beta-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002337; Hemoglobin_b.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00814; BETAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:6157408"
FT CHAIN 2..147
FT /note="Hemoglobin subunit gamma"
FT /id="PRO_0000053259"
FT BINDING 64
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT BINDING 93
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ SEQUENCE 147 AA; 16101 MW; 8854449B26A9C87E CRC64;
MGHFTEEDKA TITSLWGKVN VEDAGGETLG RLLVVYPWTQ RFFDSFGNLS SASAIMGNPK
VKAHGKKVLT SLGDAIKNLD DLKGTFAQLS ELHCDKLHVD PENFRLLGNV LVTVLAIHFG
KEFTPEVQAS WQKMVAGVAS ALSSRYH
