ID   HBG_MACNE               Reviewed;         146 AA.
AC   P02097;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Hemoglobin subunit gamma;
DE   AltName: Full=Gamma-globin;
DE   AltName: Full=Hemoglobin gamma chain;
GN   Name=HBG;
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=105752; DOI=10.1021/bi00570a014;
RA   Nute P.E., Mahoney W.C.;
RT   "Complete amino acid sequence of the gamma chain from the major fetal
RT   hemoglobin of the pig-tailed macaque, Macaca nemestrina.";
RL   Biochemistry 18:467-472(1979).
CC   -!- FUNCTION: Gamma chains make up the fetal hemoglobin F, in combination
CC       with alpha chains.
CC   -!- SUBUNIT: Heterotetramer of two alpha chains and two gamma chains in
CC       fetal hemoglobin (Hb F).
CC   -!- TISSUE SPECIFICITY: Red blood cells.
CC   -!- MISCELLANEOUS: The gamma-slow sequence is shown. The residues
CC       responsible for the gamma-fast sequence are not known.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02413; HGMQP.
DR   AlphaFoldDB; P02097; -.
DR   SMR; P02097; -.
DR   STRING; 9545.ENSMNEP00000013722; -.
DR   OMA; WRKVNVE; -.
DR   Proteomes; UP000233120; Whole Genome Shotgun Assembly.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..146
FT                   /note="Hemoglobin subunit gamma"
FT                   /id="PRO_0000053260"
FT   BINDING         63
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         92
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   146 AA;  15989 MW;  C180EEFEF50359C4 CRC64;
     GHFTEEDKAT ITSLWGKVNV EDAGGETLGR LLVVYPWTQR FFDSFGNLSS ASAIMGNPKV
     KAHGKKVLTS LGDAIKNLDD LKGTFAQLSE LHCDKLHVDP ENFRLLGNVL VTVLAIRFGK
     EFTPEVQASW QKMVAGVASA LSSRYH