ID   HBL3_ORYSJ              Reviewed;         169 AA.
AC   Q94FT8; Q10PH3;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Non-symbiotic hemoglobin 3;
DE   AltName: Full=ORYsa GLB1c;
DE   AltName: Full=rHb3;
GN   Name=HB3; Synonyms=GLB1C; OrderedLocusNames=Os03g0234000, LOC_Os03g13150;
GN   ORFNames=OJ1175C11.4;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RA   Lira-Ruan V., Ross E.J.H., Sarath G., Klucas R.V., Arredondo-Peter R.;
RT   "Mapping and analysis of a hemoglobin gene family from rice (Oryza
RT   sativa).";
RL   Plant Physiol. Biochem. 40:199-202(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [6]
RP   INDUCTION.
RC   STRAIN=cv. Jackson;
RX   PubMed=11448759; DOI=10.1016/s0168-9452(01)00411-3;
RA   Lira-Ruan V., Sarath G., Klucas R.V., Arredondo-Peter R.;
RT   "Synthesis of hemoglobins in rice (Oryza sativa var. Jackson) plants
RT   growing in normal and stress conditions.";
RL   Plant Sci. 161:279-287(2001).
CC   -!- FUNCTION: May not function as an oxygen storage or transport protein,
CC       but might act as an oxygen sensor or play a role in electron transfer,
CC       possibly to a bound oxygen molecule.
CC   -!- SUBUNIT: Dimer. {ECO:0000305}.
CC   -!- INDUCTION: By flooding and etiolating but not by oxidative, nitrosative
CC       or hormonal stresses. {ECO:0000269|PubMed:11448759}.
CC   -!- SIMILARITY: Belongs to the plant globin family. {ECO:0000305}.
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DR   EMBL; AF335504; AAK72230.1; -; Genomic_DNA.
DR   EMBL; AC103891; AAM19124.1; -; Genomic_DNA.
DR   EMBL; DP000009; ABF94823.1; -; Genomic_DNA.
DR   EMBL; AP008209; BAF11391.1; -; Genomic_DNA.
DR   EMBL; AP014959; BAS83134.1; -; Genomic_DNA.
DR   RefSeq; XP_015629792.1; XM_015774306.1.
DR   AlphaFoldDB; Q94FT8; -.
DR   SMR; Q94FT8; -.
DR   STRING; 4530.OS03T0234000-00; -.
DR   PaxDb; Q94FT8; -.
DR   PRIDE; Q94FT8; -.
DR   EnsemblPlants; Os03t0234000-00; Os03t0234000-00; Os03g0234000.
DR   GeneID; 4332167; -.
DR   Gramene; Os03t0234000-00; Os03t0234000-00; Os03g0234000.
DR   KEGG; osa:4332167; -.
DR   eggNOG; KOG3378; Eukaryota.
DR   HOGENOM; CLU_003827_11_2_1; -.
DR   InParanoid; Q94FT8; -.
DR   OMA; MRQGYQD; -.
DR   OrthoDB; 1379813at2759; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR001032; Leghaemoglobin.
DR   InterPro; IPR019824; Leghaemoglobin_Fe_BS.
DR   PANTHER; PTHR22924; PTHR22924; 1.
DR   Pfam; PF00042; Globin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
DR   PROSITE; PS00208; PLANT_GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Reference proteome.
FT   CHAIN           1..169
FT                   /note="Non-symbiotic hemoglobin 3"
FT                   /id="PRO_0000193023"
FT   BINDING         76
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         111
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   169 AA;  18569 MW;  FD87AB31F307397A CRC64;
     MAANGSNVVS RGAVRFTEEQ EALVLKSWAI MKNDSAHIGH RFFLKIFEVA PSARQLFSFL
     RNSDVPLEKN PKLKIHAMAV FVMTCEAAAQ LRKTGRVTVR DTTIKRLGST HFKNGVSDAH
     FEVAKFALLE TIKEAVPASM WSPAMKGAWG EAYDHLVAAI KQGMKPAAA