HBM_BOVIN
ID HBM_BOVIN Reviewed; 141 AA.
AC A1A4Q3;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Hemoglobin subunit mu;
DE AltName: Full=Hemoglobin mu chain;
DE AltName: Full=Mu-globin;
GN Name=HBM;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal lung;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; BC126805; AAI26806.1; -; mRNA.
DR RefSeq; NP_001077237.1; NM_001083768.2.
DR AlphaFoldDB; A1A4Q3; -.
DR SMR; A1A4Q3; -.
DR STRING; 9913.ENSBTAP00000051901; -.
DR PaxDb; A1A4Q3; -.
DR PRIDE; A1A4Q3; -.
DR Ensembl; ENSBTAT00000054450; ENSBTAP00000051901; ENSBTAG00000038757.
DR GeneID; 100140603; -.
DR KEGG; bta:100140603; -.
DR CTD; 3042; -.
DR VEuPathDB; HostDB:ENSBTAG00000038757; -.
DR VGNC; VGNC:29766; HBM.
DR eggNOG; KOG3378; Eukaryota.
DR GeneTree; ENSGT00940000163447; -.
DR HOGENOM; CLU_003827_10_2_1; -.
DR InParanoid; A1A4Q3; -.
DR OMA; EMHAAWD; -.
DR OrthoDB; 1379813at2759; -.
DR TreeFam; TF332328; -.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000038757; Expressed in biceps femoris and 20 other tissues.
DR ExpressionAtlas; A1A4Q3; baseline and differential.
DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR CDD; cd08927; Hb-alpha-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR002338; Hemoglobin_a-typ.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00612; ALPHAHAEM.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Metal-binding; Oxygen transport; Reference proteome; Transport.
FT CHAIN 1..141
FT /note="Hemoglobin subunit mu"
FT /id="PRO_0000282854"
FT BINDING 58
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT BINDING 87
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ SEQUENCE 141 AA; 15937 MW; B23F23344CB462E2 CRC64;
MLSAQERAHI TQVWDLIAGH EAPFGAELLR RLFTVYPSTK VYFRHLGDHP DEVQLLSHGQ
RMLQAVGVAV QYMDNLRAVL SPLADLHAQV LRVDPTNFPL VIQCFQVVLA SHLQGEFTVE
MQAAWDKFLT GVAVVLTEKY R
