ID   HBP1_BOVIN              Reviewed;         512 AA.
AC   Q2KJ34;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=HMG box-containing protein 1;
DE   AltName: Full=HMG box transcription factor 1;
DE   AltName: Full=High mobility group box transcription factor 1;
GN   Name=HBP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that binds to the promoter region
CC       of target genes. Plays a role in the regulation of the cell cycle and
CC       of the Wnt pathway. Binds preferentially to the sequence 5'-
CC       TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by
CC       interaction with RB1. Disrupts the interaction between DNA and TCF4 (By
CC       similarity). {ECO:0000250|UniProtKB:O60381}.
CC   -!- SUBUNIT: Binds TCF4 (By similarity). Binds RB1. Binds the second PAH
CC       repeat of SIN3A (By similarity). {ECO:0000250|UniProtKB:O60381,
CC       ECO:0000250|UniProtKB:Q8R316}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- PTM: Ubiquitinated by the CTLH E3 ubiquitin-protein ligase complex,
CC       leading to subsequent proteasomal degradation.
CC       {ECO:0000250|UniProtKB:O60381}.
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DR   EMBL; BC105542; AAI05543.1; -; mRNA.
DR   AlphaFoldDB; Q2KJ34; -.
DR   SMR; Q2KJ34; -.
DR   STRING; 9913.ENSBTAP00000007265; -.
DR   PaxDb; Q2KJ34; -.
DR   PRIDE; Q2KJ34; -.
DR   eggNOG; ENOG502QR1P; Eukaryota.
DR   InParanoid; Q2KJ34; -.
DR   OrthoDB; 1641977at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR003652; Ataxin_AXH_dom.
DR   InterPro; IPR036096; Ataxin_AXH_dom_sf.
DR   InterPro; IPR039655; HBP1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   PANTHER; PTHR15499; PTHR15499; 1.
DR   Pfam; PF08517; AXH; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00536; AXH; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF102031; SSF102031; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS51148; AXH; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Ubl conjugation; Wnt signaling pathway.
FT   CHAIN           1..512
FT                   /note="HMG box-containing protein 1"
FT                   /id="PRO_0000286356"
FT   DOMAIN          201..343
FT                   /note="AXH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00496"
FT   DNA_BIND        432..500
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          151..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..180
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   512 AA;  57383 MW;  29E9C9F45ACB8D89 CRC64;
     MVWEVKSNQM PDAVQKLLLV MDKRAPGVSD SLQLLQCKET LPSSPGYNSC DEHMELDDLP
     ELQAVQSDPT PSAIYQLSSD VSHQEYPRPS WNQNTSEISE NTYRENEVDW LTELANIATS
     PQSPLMQCSF YNRSSPVHII ATSKSLHSYA RPPPVASSKG EPAFPHHWKE QTPVRHERAN
     SESESGIFCM SSLSDDDDLG WCNSWPSTAW HCFLKGTRLC FHKGSNKEWQ NVEDFARTEG
     CDNEEDLQMG THKDYGSDGL KLLSHEESVS FGESVLKLTF DPGTVEDGLL TVECKLDHPF
     YVKNKGWSSF YPSLTVVQHG IPCCEIHIGD VCLPPGHPDA INFDDSGVFD TFKSYDFTPM
     DSSAVYVLSS MARQRRASLS CGGPGGQDFE RSGFSKNCGS PGSSQLSSSS LYAKAVKTHS
     SGTVSATSPN KCKRPMNAFM LFAKKYRVEY TQMYPGKDNR AISVILGDRW KKMKNEERRM
     YTLEAKALAE EQKRLNPDCW KRKRTNSGSQ QH