ID   HBP1_PONAB              Reviewed;         514 AA.
AC   Q5R7I3;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=HMG box-containing protein 1;
DE   AltName: Full=HMG box transcription factor 1;
DE   AltName: Full=High mobility group box transcription factor 1;
GN   Name=HBP1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that binds to the promoter region
CC       of target genes. Plays a role in the regulation of the cell cycle and
CC       of the Wnt pathway. Binds preferentially to the sequence 5'-
CC       TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by
CC       interaction with RB1. Disrupts the interaction between DNA and TCF4 (By
CC       similarity). {ECO:0000250|UniProtKB:O60381}.
CC   -!- SUBUNIT: Binds TCF4 (By similarity). Binds RB1. Binds the second PAH
CC       repeat of SIN3A (By similarity). {ECO:0000250|UniProtKB:O60381,
CC       ECO:0000250|UniProtKB:Q8R316}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- PTM: Ubiquitinated by the CTLH E3 ubiquitin-protein ligase complex,
CC       leading to subsequent proteasomal degradation.
CC       {ECO:0000250|UniProtKB:O60381}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH92277.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR860133; CAH92277.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001126331.1; NM_001132859.1.
DR   AlphaFoldDB; Q5R7I3; -.
DR   SMR; Q5R7I3; -.
DR   STRING; 9601.ENSPPYP00000020062; -.
DR   GeneID; 100173312; -.
DR   KEGG; pon:100173312; -.
DR   CTD; 26959; -.
DR   eggNOG; ENOG502QR1P; Eukaryota.
DR   InParanoid; Q5R7I3; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR003652; Ataxin_AXH_dom.
DR   InterPro; IPR036096; Ataxin_AXH_dom_sf.
DR   InterPro; IPR039655; HBP1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   PANTHER; PTHR15499; PTHR15499; 1.
DR   Pfam; PF08517; AXH; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00536; AXH; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF102031; SSF102031; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS51148; AXH; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation; Ubl conjugation; Wnt signaling pathway.
FT   CHAIN           1..514
FT                   /note="HMG box-containing protein 1"
FT                   /id="PRO_0000048548"
FT   DOMAIN          203..345
FT                   /note="AXH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00496"
FT   DNA_BIND        434..502
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          150..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   514 AA;  57717 MW;  99B00AB5B9C977BE CRC64;
     MVWEVKTNQM PNAVQKLLLV MDKRASGMND SLELLQCNEN LPSSPGYNSC DEHMELDDLP
     ELQAVQSDPT QSGMYQLSSD VSHQEYPRSS WNQNTSDIPE TTYRENEVDW LTELANIATS
     PQSPLMQCSF YNRSSPVHII ATSKSLHSYA RPPPVSSSSK SEPAFPHHHW KEETPVRHER
     ANSESESGIF CMSSLSDDDD LGWCNSWPST VWHCFLKGTR LCFHKGSNKE WQDVEDFARA
     EGCDNEEDLQ MGIHKGYGSD GLKLLSHEES VSFGESVLKL TFDPGTVEDG LLTVECKLDH
     PFYVKNKGWS SFYPSLTVVQ HGIPCCEVHI GDVRLPPGHL DAINFDDSGV FDTFKSYDFT
     PMDSSAVYVL SSMARQRRAS LSCGGPGGQD FARSGFSKNC GSPGSSQLSS SSLYAKAVKN
     HSSGTVSATS PNKCKRPMNA FMLFAKKYRV EYTQMYPGKD NRAISVILGD RWKKMKNEER
     RMYTLEAKAL AEEQKRLNPD CWKRKRTNSS SQQH