ID   HBPI_CAIMO              Reviewed;         142 AA.
AC   P04243;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Hemoglobin subunit pi;
DE   AltName: Full=Hemoglobin pi chain;
DE   AltName: Full=Hemoglobin pi' chain;
DE   AltName: Full=Pi-globin;
OS   Cairina moschata (Muscovy duck).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Cairina.
OX   NCBI_TaxID=8855;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6530142; DOI=10.1016/0378-1119(84)90044-1;
RA   Erbil C., Niessing J.;
RT   "Chromosomal arrangement of the duck alpha-globin genes and primary
RT   structure of the embryonic alpha-globin gene pi.";
RL   Gene 32:161-170(1984).
CC   -!- FUNCTION: The pi' chain is the counterpart of the alpha chain in the
CC       major early embryonic hemoglobin P.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; M10141; AAA49150.1; -; Genomic_DNA.
DR   PIR; A02335; HADKP.
DR   AlphaFoldDB; P04243; -.
DR   SMR; P04243; -.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd08927; Hb-alpha-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002338; Hemoglobin_a-typ.
DR   InterPro; IPR002339; Hemoglobin_pi.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00612; ALPHAHAEM.
DR   PRINTS; PR00815; PIHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Metal-binding; Oxygen transport; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..142
FT                   /note="Hemoglobin subunit pi"
FT                   /id="PRO_0000053271"
FT   BINDING         59
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         88
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   142 AA;  15719 MW;  A6B8FA8402975C68 CRC64;
     MTLTQAEKAA VITIWTKVAT QADAIGAESL ERLFSSYPQT KTYFPHFDLS QGSTQLRGHG
     SKVMNAIGEA VKNIDDIRGA LAKLSELHAY ILRVDPVNFK LLCHCILCSV AARYPSDFTP
     EVHAAWDKFL SSVSSVLTEK YR