ID   ANDP_DROMA              Reviewed;          57 AA.
AC   O16825; Q8WSV3;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 2.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Andropin;
DE   Flags: Precursor;
GN   Name=Anp;
OS   Drosophila mauritiana (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11965438; DOI=10.1007/s00239-001-0062-5;
RA   Date-Ito A., Kasahara K., Sawai H., Chigusa S.I.;
RT   "Rapid evolution of the male-specific antibacterial protein andropin gene
RT   in Drosophila.";
RL   J. Mol. Evol. 54:665-670(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44.
RC   STRAIN=M31;
RX   PubMed=9335607; DOI=10.1093/genetics/147.2.713;
RA   Clark A.G., Wang L.;
RT   "Molecular population genetics of Drosophila immune system genes.";
RL   Genetics 147:713-724(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-57.
RC   STRAIN=Montemayor;
RX   PubMed=9725836; DOI=10.1093/genetics/150.1.157;
RA   Ramos-Onsins S., Aguade M.;
RT   "Molecular evolution of the Cecropin multigene family in Drosophila:
RT   functional genes vs pseudogenes.";
RL   Genetics 150:157-171(1998).
CC   -!- FUNCTION: Male-specific peptide with moderate activity against Gram-
CC       positive bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Ejaculatory duct of adult males.
CC   -!- INDUCTION: In response to mating.
CC   -!- SIMILARITY: Belongs to the andropin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB047041; BAB78546.1; -; Genomic_DNA.
DR   EMBL; AF018993; AAB82490.1; -; Genomic_DNA.
DR   EMBL; Y16863; CAA76487.1; -; Genomic_DNA.
DR   AlphaFoldDB; O16825; -.
DR   SMR; O16825; -.
DR   FlyBase; FBgn0023321; Dmau\Anp.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0006962; P:male-specific antibacterial humoral response; ISS:UniProtKB.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Immunity; Innate immunity; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..57
FT                   /note="Andropin"
FT                   /id="PRO_0000004951"
SQ   SEQUENCE   57 AA;  6133 MW;  FC54A5651DA09AAE CRC64;
     MKYFVVLVVL ALILAITVGP SDAVFIDILD KMENAIHKAA QAGIGIAKPI EKMILPK