ANDP_DROME
ID ANDP_DROME Reviewed; 57 AA.
AC P21663; A9UNE4; O16822; O16823; O16824; Q6LAI1; Q9VA90;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Andropin;
DE Flags: Precursor;
GN Name=Anp; Synonyms=ANR; ORFNames=CG1361;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Canton-S;
RX PubMed=1899226; DOI=10.1002/j.1460-2075.1991.tb07932.x;
RA Samakovlis C., Kylsten P., Kimbrell D.A., Engstroem A., Hultmark D.;
RT "The andropin gene and its product, a male-specific antibacterial peptide
RT in Drosophila melanogaster.";
RL EMBO J. 10:163-169(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS PHE-9; SER-34; VAL-44 AND
RP ASN-48.
RC STRAIN=B009, B141, B205, B316, Z10, Z18, Z22, and Z24;
RX PubMed=9335607; DOI=10.1093/genetics/147.2.713;
RA Clark A.G., Wang L.;
RT "Molecular population genetics of Drosophila immune system genes.";
RL Genetics 147:713-724(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K-1, K-2, K-3, K-4, and K-5;
RX PubMed=11965438; DOI=10.1007/s00239-001-0062-5;
RA Date-Ito A., Kasahara K., Sawai H., Chigusa S.I.;
RT "Rapid evolution of the male-specific antibacterial protein andropin gene
RT in Drosophila.";
RL J. Mol. Evol. 54:665-670(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-57.
RC STRAIN=M11, M2, M26, M36, M40, M47, M54, M55, and M66;
RX PubMed=9725836; DOI=10.1093/genetics/150.1.157;
RA Ramos-Onsins S., Aguade M.;
RT "Molecular evolution of the Cecropin multigene family in Drosophila:
RT functional genes vs pseudogenes.";
RL Genetics 150:157-171(1998).
CC -!- FUNCTION: Male-specific peptide with moderate activity against Gram-
CC positive bacteria.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Ejaculatory duct of adult males.
CC -!- INDUCTION: In response to mating.
CC -!- SIMILARITY: Belongs to the andropin family. {ECO:0000305}.
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DR EMBL; X16972; CAA34842.1; -; Genomic_DNA.
DR EMBL; X56726; CAA40046.1; -; Genomic_DNA.
DR EMBL; AF018985; AAB82482.1; -; Genomic_DNA.
DR EMBL; AF018986; AAB82483.1; -; Genomic_DNA.
DR EMBL; AF018987; AAB82484.1; -; Genomic_DNA.
DR EMBL; AF018988; AAB82485.1; -; Genomic_DNA.
DR EMBL; AF018989; AAB82486.1; -; Genomic_DNA.
DR EMBL; AF018990; AAB82487.1; -; Genomic_DNA.
DR EMBL; AF018991; AAB82488.1; -; Genomic_DNA.
DR EMBL; AF018992; AAB82489.1; -; Genomic_DNA.
DR EMBL; AB047046; BAB78551.1; -; Genomic_DNA.
DR EMBL; AB047047; BAB78552.1; -; Genomic_DNA.
DR EMBL; AB047048; BAB78553.1; -; Genomic_DNA.
DR EMBL; AB047049; BAB78554.1; -; Genomic_DNA.
DR EMBL; AB047050; BAB78555.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF57024.1; -; Genomic_DNA.
DR EMBL; BT031308; ABY20549.1; -; mRNA.
DR EMBL; Y16852; CAA76424.1; -; Genomic_DNA.
DR EMBL; Y16853; CAA76430.1; -; Genomic_DNA.
DR EMBL; Y16854; CAA76436.1; -; Genomic_DNA.
DR EMBL; Y16855; CAA76442.1; -; Genomic_DNA.
DR EMBL; Y16856; CAA76448.1; -; Genomic_DNA.
DR EMBL; Y16857; CAA76454.1; -; Genomic_DNA.
DR EMBL; Y16858; CAA76460.1; -; Genomic_DNA.
DR EMBL; Y16859; CAA76466.1; -; Genomic_DNA.
DR EMBL; Y16861; CAA76476.1; -; Genomic_DNA.
DR PIR; S13450; S13450.
DR RefSeq; NP_001287605.1; NM_001300676.1.
DR RefSeq; NP_524587.1; NM_079848.3.
DR AlphaFoldDB; P21663; -.
DR SMR; P21663; -.
DR BioGRID; 68451; 1.
DR DIP; DIP-21373N; -.
DR IntAct; P21663; 5.
DR STRING; 7227.FBpp0084976; -.
DR PaxDb; P21663; -.
DR DNASU; 43595; -.
DR EnsemblMetazoa; FBtr0085611; FBpp0084976; FBgn0000094.
DR EnsemblMetazoa; FBtr0346141; FBpp0311969; FBgn0000094.
DR GeneID; 43595; -.
DR KEGG; dme:Dmel_CG1361; -.
DR UCSC; CG1361-RA; d. melanogaster.
DR CTD; 43595; -.
DR FlyBase; FBgn0000094; Anp.
DR VEuPathDB; VectorBase:FBgn0000094; -.
DR HOGENOM; CLU_2998613_0_0_1; -.
DR OMA; VETALHN; -.
DR OrthoDB; 1890984at2759; -.
DR PhylomeDB; P21663; -.
DR SignaLink; P21663; -.
DR BioGRID-ORCS; 43595; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43595; -.
DR PRO; PR:P21663; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0000094; Expressed in male reproductive gland and 10 other tissues.
DR ExpressionAtlas; P21663; baseline and differential.
DR Genevisible; P21663; DM.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; HDA:FlyBase.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0006962; P:male-specific antibacterial humoral response; IDA:UniProtKB.
DR GO; GO:0009617; P:response to bacterium; TAS:FlyBase.
DR GO; GO:0019953; P:sexual reproduction; HEP:FlyBase.
DR InterPro; IPR000875; Cecropin.
DR Pfam; PF00272; Cecropin; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Immunity; Innate immunity; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PEPTIDE 24..57
FT /note="Andropin"
FT /id="PRO_0000004952"
FT VARIANT 9
FT /note="V -> F (in strain: B316)"
FT /evidence="ECO:0000269|PubMed:9335607"
FT VARIANT 34
FT /note="N -> S (in strain: B205)"
FT /evidence="ECO:0000269|PubMed:9335607"
FT VARIANT 44
FT /note="I -> V (in strain: B316)"
FT /evidence="ECO:0000269|PubMed:9335607"
FT VARIANT 48
FT /note="K -> N (in strain: Z22)"
FT /evidence="ECO:0000269|PubMed:9335607"
SQ SEQUENCE 57 AA; 6151 MW; EEA8CCCF59A09AB5 CRC64;
MKYFVVLVVL ALILAISVGP SDAVFIDILD KVENAIHNAA QVGIGFAKPF EKLINPK
