ID   ANDP_DROOR              Reviewed;          67 AA.
AC   Q8WSV0;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Andropin;
DE   Flags: Precursor;
GN   Name=Anp;
OS   Drosophila orena (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7233;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11965438; DOI=10.1007/s00239-001-0062-5;
RA   Date-Ito A., Kasahara K., Sawai H., Chigusa S.I.;
RT   "Rapid evolution of the male-specific antibacterial protein andropin gene
RT   in Drosophila.";
RL   J. Mol. Evol. 54:665-670(2002).
CC   -!- FUNCTION: Male-specific peptide with moderate activity against Gram-
CC       positive bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Ejaculatory duct of adult males.
CC   -!- INDUCTION: In response to mating.
CC   -!- SIMILARITY: Belongs to the andropin family. {ECO:0000305}.
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DR   EMBL; AB047045; BAB78550.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8WSV0; -.
DR   FlyBase; FBgn0046938; Dore\Anp.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0006962; P:male-specific antibacterial humoral response; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Immunity; Innate immunity; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..67
FT                   /note="Andropin"
FT                   /id="PRO_0000004953"
SQ   SEQUENCE   67 AA;  7314 MW;  BD96162027D5A691 CRC64;
     MKYFLVLVVL TLILAISVGQ SDALFVDIID NVENAIHKAA KTGIGMVKPI ENIFIPNQQK
     KSTEASN