ID   ANDP_DROSE              Reviewed;          57 AA.
AC   Q8WSV2; B4HZP0; P81687;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Andropin;
DE   Flags: Precursor;
GN   Name=Anp; ORFNames=GM12868;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11965438; DOI=10.1007/s00239-001-0062-5;
RA   Date-Ito A., Kasahara K., Sawai H., Chigusa S.I.;
RT   "Rapid evolution of the male-specific antibacterial protein andropin gene
RT   in Drosophila.";
RL   J. Mol. Evol. 54:665-670(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 47-57.
RC   STRAIN=Montemayor;
RX   PubMed=9725836; DOI=10.1093/genetics/150.1.157;
RA   Ramos-Onsins S., Aguade M.;
RT   "Molecular evolution of the Cecropin multigene family in Drosophila:
RT   functional genes vs pseudogenes.";
RL   Genetics 150:157-171(1998).
CC   -!- FUNCTION: Male-specific peptide with moderate activity against Gram-
CC       positive bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Ejaculatory duct of adult males.
CC   -!- INDUCTION: In response to mating.
CC   -!- SIMILARITY: Belongs to the andropin family. {ECO:0000305}.
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DR   EMBL; AB047042; BAB78547.1; -; Genomic_DNA.
DR   EMBL; CH480819; EDW53497.1; -; Genomic_DNA.
DR   EMBL; Y16862; CAA76482.1; -; Genomic_DNA.
DR   RefSeq; XP_002037338.1; XM_002037302.1.
DR   AlphaFoldDB; Q8WSV2; -.
DR   SMR; Q8WSV2; -.
DR   EnsemblMetazoa; FBtr0195853; FBpp0194345; FBgn0025847.
DR   GeneID; 6612844; -.
DR   KEGG; dse:6612844; -.
DR   HOGENOM; CLU_2998613_0_0_1; -.
DR   OMA; VETALHN; -.
DR   PhylomeDB; Q8WSV2; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0006962; P:male-specific antibacterial humoral response; ISS:UniProtKB.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Immunity; Innate immunity; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..57
FT                   /note="Andropin"
FT                   /id="PRO_0000004954"
SQ   SEQUENCE   57 AA;  6177 MW;  C36BA5614CA7E853 CRC64;
     MKYFVVLVVL ALILAITVDP SDAVFIDILD KMENAIHKAA QAGIGLAKPI ENMILPK