ID   ANDP_DROSI              Reviewed;          60 AA.
AC   Q8WSV4; Q8WSV5;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Andropin;
DE   Flags: Precursor;
GN   Name=Anp;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Australia, and New Caledonia;
RX   PubMed=11965438; DOI=10.1007/s00239-001-0062-5;
RA   Date-Ito A., Kasahara K., Sawai H., Chigusa S.I.;
RT   "Rapid evolution of the male-specific antibacterial protein andropin gene
RT   in Drosophila.";
RL   J. Mol. Evol. 54:665-670(2002).
CC   -!- FUNCTION: Male-specific peptide with moderate activity against Gram-
CC       positive bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Ejaculatory duct of adult males.
CC   -!- INDUCTION: In response to mating.
CC   -!- SIMILARITY: Belongs to the andropin family. {ECO:0000305}.
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DR   EMBL; AB047039; BAB78544.1; -; Genomic_DNA.
DR   EMBL; AB047040; BAB78545.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8WSV4; -.
DR   SMR; Q8WSV4; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0006962; P:male-specific antibacterial humoral response; ISS:UniProtKB.
DR   InterPro; IPR000875; Cecropin.
DR   Pfam; PF00272; Cecropin; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Immunity; Innate immunity; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         24..60
FT                   /note="Andropin"
FT                   /id="PRO_0000004955"
FT   VARIANT         45
FT                   /note="G -> N (in strain: New Caledonia)"
FT   VARIANT         58
FT                   /note="L -> S (in strain: New Caledonia)"
SQ   SEQUENCE   60 AA;  6431 MW;  89BDA18D54A5741D CRC64;
     MKYFVVLVVL ALILAIAVGP SDAVFIDILD KMENAIHKAA QAGIGIAKPI ENMILPKLTK