ID   HBT_PIG                 Reviewed;         146 AA.
AC   P04246;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-1987, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Hemoglobin subunit theta;
DE   AltName: Full=Hemoglobin theta chain;
DE   AltName: Full=Theta-globin;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6724525;
RA   Bieber F.A., Braunitzer G.;
RT   "Pre- and perinatal oxygen transport in mammals: the embryonic hemoglobins
RT   of the domestic pig (Sus scrofa domestica).";
RL   Hoppe-Seyler's Z. Physiol. Chem. 365:321-334(1984).
CC   -!- MISCELLANEOUS: Hemoglobin theta chain is an embryonic beta-type chain.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02422; HTPG.
DR   AlphaFoldDB; P04246; -.
DR   SMR; P04246; -.
DR   IntAct; P04246; 1.
DR   PeptideAtlas; P04246; -.
DR   HOGENOM; CLU_003827_10_0_1; -.
DR   OMA; INGLWSK; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; P04246; SS.
DR   GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR   GO; GO:0005833; C:hemoglobin complex; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0031721; F:hemoglobin alpha binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR   GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR   GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR   GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..146
FT                   /note="Hemoglobin subunit theta"
FT                   /id="PRO_0000053275"
FT   BINDING         63
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         92
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   146 AA;  15980 MW;  C744BFBD6B539488 CRC64;
     VHFTAEEKSV ITGLWGKVNV EETGGEAVGR LLVVYPWTQR FFDSFGNMSS PSAIMGNPKV
     KAHGKKVLTS FGDAVKNMDN LKGTFAKLSE LHCDKLHVDP ENFRLLGNMI VIILASHFGG
     EFTPEVQAAW QKLVAGVATA LAHKYH