ID   HBX10_DICDI             Reviewed;         638 AA.
AC   Q54PU1;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Homeobox protein 10;
DE            Short=DdHbx-10;
GN   Name=hbx10; ORFNames=DDB_G0284293;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Putative transcription factor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; AAFI02000064; EAL65335.1; -; Genomic_DNA.
DR   RefSeq; XP_638704.1; XM_633612.1.
DR   AlphaFoldDB; Q54PU1; -.
DR   SMR; Q54PU1; -.
DR   STRING; 44689.DDB0220476; -.
DR   PaxDb; Q54PU1; -.
DR   EnsemblProtists; EAL65335; EAL65335; DDB_G0284293.
DR   GeneID; 8624535; -.
DR   KEGG; ddi:DDB_G0284293; -.
DR   dictyBase; DDB_G0284293; hbx10.
DR   eggNOG; KOG0490; Eukaryota.
DR   HOGENOM; CLU_429259_0_0_1; -.
DR   InParanoid; Q54PU1; -.
DR   OMA; VKRGGPF; -.
DR   PRO; PR:Q54PU1; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..638
FT                   /note="Homeobox protein 10"
FT                   /id="PRO_0000388794"
FT   DNA_BIND        301..360
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          23..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          76..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          195..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          381..431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..431
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        448..524
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        533..638
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   638 AA;  68990 MW;  7CCE0671DD05DD4C CRC64;
     MQEIITNNIP TFKLQNDVDM VEETQPTTPT TQPTTPTTNT ISTTTNTITS TLNTNNISPI
     LEESEEEDSN ELIIETDENN TSVSATGTTP TSSSSSSSSS PTNTTTTTTT TTTATTANND
     FKNITSNNIN KTNSNVNTNS EIKNIDNSIM NSLNRYNNIT TASPSNSTMI TMKSAISSLD
     EIVKNTMKAQ RESFIANEDK ESLPEPQTNS NVNGNEEAKD EKEIHLLAKI LLNFSSNGIA
     VPNLSESSPA VLNTKLKDSS NLVPYGGDLN TSVNGVVGNS SGMVDLSAST GDLLGSLNAA
     NKKKRQRTSP EQLAILEQIF ETDKMPSQQI RVRLANQLGM SSRRVQIWFQ NKRAKVKRGG
     PFGKGDDNDD LFAEGEDIID EDEDEDSSLT IDESGNNNNN SGNNNNNNNN GIMGGHGMLS
     SSPTNLNTSS DNIVPSISPM LTSININSSS STPTLQSVNL LNNTNNNNNN NNNNNNNNNN
     NNNNNNNHTT TTTTTTTTTT TSSSPPLTSF NFQLNQSLNK LTSPPSPPSI VPSPNKKTKQ
     MGGFSLNSTA SSLPSFPQIK LNSSSKHIPT DKQNNSDFSN FNNNNNNNNN NNNNNNNNNN
     INNNGNNNSN NNDSNNNNNK SNFSDYQPLK FHNSIVKN