HBX12_DICDI
ID HBX12_DICDI Reviewed; 846 AA.
AC Q54LB3;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Homeobox protein 12;
DE Short=DdHbx-12;
GN Name=hbx12; ORFNames=DDB_G0286733;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Putative transcription factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR EMBL; AAFI02000089; EAL64122.1; -; Genomic_DNA.
DR RefSeq; XP_637648.1; XM_632556.1.
DR AlphaFoldDB; Q54LB3; -.
DR SMR; Q54LB3; -.
DR STRING; 44689.DDB0220477; -.
DR PaxDb; Q54LB3; -.
DR EnsemblProtists; EAL64122; EAL64122; DDB_G0286733.
DR GeneID; 8625788; -.
DR KEGG; ddi:DDB_G0286733; -.
DR dictyBase; DDB_G0286733; hbx12.
DR eggNOG; ENOG502RHA1; Eukaryota.
DR HOGENOM; CLU_336924_0_0_1; -.
DR InParanoid; Q54LB3; -.
DR PRO; PR:Q54LB3; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..846
FT /note="Homeobox protein 12"
FT /id="PRO_0000388795"
FT DNA_BIND 773..835
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 78..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 553..604
FT /evidence="ECO:0000255"
FT COMPBIAS 163..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..551
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 96717 MW; 506230C0C7615109 CRC64;
MTSTANNNTS FYCNNNNSNN NININCCSNT GHNGNNTTET TLTTVNEERC APTPTPTSTP
PHGSALNIQN SNNGCNNIIG SSSNTLSTPS VQATPPTPPP SSSSLLVQPM IVTPSPVVAT
TSSLITNDDN LNSSTNYLML PHQAQSSAMT IVQPPPPSTP LSSSSTVVPA STPPPSVMTP
ITTIQTTATP PSLQPTIHHQ TALSFLGYTY NEQYQQNICQ LYHQLNANGN GNGNGNGNHN
NNNNNYNYNN NSFYQHQQHQ HGLYYNQFPI PMNSSVPIIP TQQYIGTKQP QSQSQSQQLQ
PQPQPQPQLQ PQLQSQPQSQ QLKRKEASYH NNNNNNNNNN NNNNNNNNNN NNPYNRPTKK
IMVSQGLPPI SSSPSFQNLN NKYFDFNQPI TRNNYNQVNY NNNNNNNNNN NNNYNNISNN
NPCNNNNNNK PNNNPNNNNS NSNKTYINKQ HRDYGYENNN NNNNKTFQQT SQQQQQQQQQ
IYKKQNCNNY IDESGDDESG EEYQNYQPYQ QYQNFKQNNK DNNNNDDDDD DDDDEEEEEE
EEDDNDNCNG NDSYDEENNN NNNNNNNNNQ FKNESIIIGD NYYEIINDRI KSIKQKLHFL
EKNSKFQWIR EKSFNFINEF TGESVVNEEL GIRGSKDFSY LKYKTLNPSL DNYITQERIE
LKNPLIKANI EKLKKDFNFE ITKINTTKSE SLEIMKSIQQ LSTTVRSPLL DRSDLKAQRN
HIHGFFTLII AHQKCLSFDF IYQMRPQSMD HQHGFSNTFT DDFTNGGGCS ISDKKNRRTL
NDQYKSFISD YFKNHSDHPY PNEDEKIIIS ALIDLSKYQR NNWFSNKRSR EKNQRIVNLK
KQIGFH
