HBX13_DICDI
ID HBX13_DICDI Reviewed; 1363 AA.
AC Q54I65;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Homeobox protein 13;
DE Short=DdHbx-13;
GN Name=hbx13; ORFNames=DDB_G0288975;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Putative transcription factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR EMBL; AAFI02000128; EAL62955.1; -; Genomic_DNA.
DR RefSeq; XP_636458.1; XM_631366.1.
DR AlphaFoldDB; Q54I65; -.
DR SMR; Q54I65; -.
DR STRING; 44689.DDB0220490; -.
DR PaxDb; Q54I65; -.
DR EnsemblProtists; EAL62955; EAL62955; DDB_G0288975.
DR GeneID; 8626897; -.
DR KEGG; ddi:DDB_G0288975; -.
DR dictyBase; DDB_G0288975; hbx13.
DR eggNOG; ENOG502RI6F; Eukaryota.
DR HOGENOM; CLU_256873_0_0_1; -.
DR InParanoid; Q54I65; -.
DR PRO; PR:Q54I65; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome.
FT CHAIN 1..1363
FT /note="Homeobox protein 13"
FT /id="PRO_0000388796"
FT DNA_BIND 1198..1261
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 66..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1001..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 15..73
FT /evidence="ECO:0000255"
FT COILED 738..789
FT /evidence="ECO:0000255"
FT COMPBIAS 130..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1077..1137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1363 AA; 156040 MW; 57579F7CCFB12274 CRC64;
MEYLKLCFYL FFFYFVMEQI QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQLQ QQQQQQQQQQ
QQQQQQQQQQ QQNPKMNNQP NETRLPSPPL LNSTVPKNEL NINHHHQHNY KINSAPLKAS
QHANEYDHNE ESLNSSNNNN NNNFNNSRPT FSSCSGNSNN TTTTTTTTTT TNPINGSVNS
NVTTTSINTI HQKFITQLKQ RLGKGIDYNN YINKLKNINN INNISKLINL SSQPDAIGKN
NNLISNTGPV AEMYDDEEFD EFDEEEDDDI SAQKLVGILS RESSSSNLSS IAPSPLLQQP
NCLPSPFING TPLLSNHSNN NNNNNNNHHH HHHHHHQKRL SIGSMDSTNH LTPLPLLHKH
TNNNNNINNN NNHNHNNILG SPNQLNRSQD FTSKNNNINN NNNNNNKIIN EENCNKGSPN
QNSSENNSEE ENEYHGGEEG NVYSVYDLNS PYFNERKQRA LSNNKSQQPP QHVPTPCTYN
DCCICAYGPP PSFFTSAPTW ADICYIALYC LTLSRPEVKY YHIKKDICTF IDCHYETICM
RKRTSIWRQT VNMTLSHPQY FEMFQQESAL ENGRKGYYGL KQIHDPYEHT ALNKRSRRKR
RHEQKMIQEE LKKNGFTNLL LNSPSIENND QHHNGYIQSY NNNSNHNNNN NNNNNNNNNN
SNNNNNNNNN NSNNNNNNNI NNNNINNNNN NNILTSPIQH HPHSHQQQHH QQQLQHQQHQ
QQQLLHQQHQ QLLHQQHQQQ LQIQYQQQQT HNNNLNQTQQ LYYNHHHHQQ QQQQQQQQQQ
HNNNNNNNNS NHNSVLTSPP LSQFPKTPLQ LSQTPQHSLS ALSSPFLKTL TIEDEDDSYN
GQVHKKLRSA KLTSVNSINS NSGMSLPMIS SPSPNLSHMQ KNRPNFDDIL NSSLSSSNTT
NSATTSSSNS ILSNSLSNIS NSSGGSGGVC ISEDYESNIQ RRKSLNNIVL NKTNKNILPK
LDDECDDEDD FHFTENEREV PVSNLKSSSF IINKNNIINQ QNYNENNNNN NNNNNNNYNI
NNINNNNNNN FDDADDENEF ENKDNINNNN NNNNNNNNNN NNNKNDKNES EFESKEKLNS
PFGSSIPNIV NNEQLSPYSQ QSLSSSSSEN PSPQWSTNGP SQTSSSKLSN STSTLINNNN
NSMSIMSINS SGNSINNTTT YNNNNNFINN NSNNNNNMEI DDDDEDGIDG IEGEDDSKKR
MRKTTRPDEK IYLEIYYQHF YENNGKHSKD ELITLSNNLN WKVNRIQRWL DNRRTKDKLK
NLRVSQERTI SFGASSTSST QTSTNSPSSQ LSPLVPNMNN NDQQSISTPS LILSQINNNQ
NNNQNNNNNN NTNNADVTLI SNNNVPNTPI MANTQSNINS LLN
